58791-75-6

Upstream product

• 862729-12-2 3-iodo-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 2380-63-4 4-Aminopyrazolo<3,4-d>pyrimidin 
• 151266-23-8 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine 

Relevant academic research and scientific papers

Microwave-assisted synthesis of N1- and C3-substituted pyrazolo[3,4-d] pyrimidine libraries

The parallel synthesis of a library N1- and C3-substituted-pyrazolo[3,4-d] pyrimidines is described. The microwave-assisted approach involves the de novo generation of the heterocyclic scaffold, facile alkylation at N1 via either a Mitsunobu or a direct alkylation reaction and arylation at C3 via a Suzuki reaction.

MODULATION OF PROTEIN TRAFFICKING

Compounds and compositions are provided for treatment or amelioration of one or more disorders characterized by defects in protein trafficking. A method of treating a disorder characterized by impaired protein trafficking includes administering to a subject or contacting a cell with a compound of Formula I: [formula here] or pharmaceutically acceptable salts or derivatives thereof.