588-09-0

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-5-(trifluoroMethoxy)nitrobenzene is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to advancements in medicinal chemistry.
Used in Agrochemical Production:
2-Chloro-5-(trifluoroMethoxy)nitrobenzene also serves as a building block in the production of agrochemicals, which are essential for enhancing crop protection and improving agricultural yields. Its incorporation into agrochemical formulations can lead to the creation of more effective and targeted pest control solutions.
Used in Dye Manufacturing:
2-Chloro-5-(trifluoroMethoxy)nitrobenzene is employed in the manufacturing process of dyes, where its chemical properties contribute to the creation of a diverse range of colorants for various applications, including textiles, plastics, and printing inks.
Used in Organic Compounds Preparation:
As a versatile building block, 2-Chloro-5-(trifluoroMethoxy)nitrobenzene is used in the preparation of various functionalized aromatic compounds. Its presence in these compounds can enhance their chemical and physical properties, broadening their potential applications in different industries.
Used in Chemical Research:
Due to its high reactivity, 2-Chloro-5-(trifluoroMethoxy)nitrobenzene is also valuable in chemical research, where it can be used to study reaction mechanisms, explore new synthetic routes, and develop innovative chemical processes.

InChI:InChI=1S/C7H3ClF3NO3/c8-5-2-1-4(15-7(9,10)11)3-6(5)12(13)14/h1-3H

Upstream product

• 461-81-4 1-chloro-4-(trifluoromethoxy)benzene 
• 1006904-72-8 silver(I) trifluoromethoxide 
• 635-22-3 4-Chloro-3-nitroaniline 

Downstream Products

• 1261791-19-8 4-chloro-2(-3)-nitrotrifluoro-methoxybenzene 

Relevant academic research and scientific papers

Co-production preparation method of o-amino trifluoromethoxy benzene and m-amino trifluoromethoxy benzene

The invention discloses a co-production preparation method of o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene, and belongs to the technical field of fine chemical engineering. Thepreparation method comprises the following steps: (1) nitration reaction: carrying out nitration reaction on 4-chlorine-trifluoromethoxybenzene to obtain a mixture of 4-chlorine-2-nitro- trifluoromethoxy benzene and 4-chlorine-3-nitro-trifluoromethoxybenzene; (2) reduction and dechlorination: carrying out reduction and dechlorination on the mixture of the 4-chloro-2-nitro-trifluoromethoxybenzene and the 4-chloro-3-nitro-trifluoromethoxybenzene to obtain o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene; and (3) rectification separation: separating the o-amino trifluoromethoxybenzene from the m-amino trifluoromethoxybenzene through rectification so as to realize co-production. The method is low in cost and high in yield, two useful chemical products are obtained at the same time, the process is simple, and industrial production is easy to achieve.

Silver-Mediated Trifluoromethoxylation of (Hetero)aryldiazonium Tetrafluoroborates

Here we report a silver-mediated trifluoromethoxylation of (hetero)aryldiazonium tetrafluoroborates by converting an aromatic amino group into an OCF3 group. This method, which can be considered to be a trifluoromethoxylation variation of the classic Sandmeyer-type reaction, uses readily available aryl and heteroaromatic amines as starting materials and AgOCF3 as trifluoromethoxylating reagents. The broad substrate scope and simple, mild reaction condition made this transformation a valuable method in constructing aryl-OCF3 bonds.

Method for trifluoro methoxylation of arylamine

The invention provides a method for synthesizing an aryltrifluoromethoxy compound from an arylamine compound. The method comprises the steps of: performing a diazotization reaction on arylamine, and performing a one-pot reaction between the obtained aryl diazonium salt and trifluoromethoxy silver in an acetonitrile solvent so as to obtain the corresponding aryltrifluoromethoxy product. The obtained product has a high yield, and the process is simple.

LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT

Fertility management can include: administering to the subject one or more doses of a compound according to Formula I so as to reduce fertility in the subject. Fertility management can also include administering an effective amount of the compound to: impair Sertoli cell function in a male subject; inhibit spermatogenesis in the subject; reduce testis weight in the subject; reduce ovary weight in a female subject; reduce serum progesterone in the female subject; impair ovarian follicle function in the female subject; causing reversible fertility in the subject. In order to return fertility, the method can include ceasing administration of the compound to the subject so as to return fertility in the subject. The compound can be administered for irreversibly sterilizing the subject.

DISUBSTITUTED [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-1H-INDOL-3-YL]-METHANONES

The present invention extends to the compound of formula I: or a prodrug, pharmaceutically acceptable salt, or solvate of said compound. Furthermore, the present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective

Lonidamine analogues and their use in male contraception and cancer treatment

Novel compounds useful for inhibiting spermatogenesis and cancer treatment, and in particular as inhibitors of heat shock proteins and/or elongation factor 1 alpha.