588-22-7

Basic information

• Product Name: 3,4-D
• Synonyms: (3,4-dichlorophenoxy)-aceticaci;3,4-da;LABOTEST-BB LT00233086;3,4-DICHLOROPHENOXYACETIC ACID;3,4-D;3,4-d (iso);3,4-D solution;3,4-Dichlorophenoxyacetic acid solution
• CAS NO: 588-22-7
• Molecular Formula: C₈H₆Cl₂O₃
• Molecular Weight: 221.04
• EINECS: 209-612-4
• Product Categories: C8;Carbonyl Compounds;Carboxylic Acids
• Mol File: 588-22-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 138-140 °C(lit.)
• Boiling Point: 316.96°C (rough estimate)
• Flash Point: 2 °C
• Appearance: White/Crystalline Powder
• Density: 1.4564 (rough estimate)
• Vapor Pressure: 1.53E-05mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• Storage Temp.: APPROX 4°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 2.99±0.10(Predicted)
• Water Solubility: 457.6mg/L(25 oC)
• CAS DataBase Reference: 3,4-D(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-D(588-22-7)
• EPA Substance Registry System: 3,4-D(588-22-7)

Safety Data

• Hazard Codes: Xi,Xn,F
• Statements: 36/37/38-36-20/21/22-11
• Safety Statements: 26-37/39-36-16
• RIDADR: 2811
• WGK Germany: 3
• RTECS: AG6830000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 588-22-7(Hazardous Substances Data)

Usage

Uses

3,4-Dichlorophenoxyacetic acid was used in the synthesis of layered organic-inorganic nanohybrid material, zinc-aluminum-3,4-dicholorophenoxyacetate.

Definition

ChEBI: A chlorophenoxyacetic acid that is phenoxyacetic acid in which the hydrogens at positions 3 and 4 of the phenyl group are replaced by chlorines.

General Description

3,4-Dichlorophenoxyacetic acid is a phenoxyacetic herbicide.

InChI:InChI=1/C8H6Cl2O3/c9-6-2-1-5(3-7(6)10)13-4-8(11)12/h1-3H,4H2,(H,11,12)

Upstream product

• 95-77-2 3,4-dichlorophenol 
• 105-36-2 ethyl bromoacetate 
• 62855-72-5 ethyl 2-(3,4-dichlorophenoxy)acetate 
• 39975-26-3 sodium 3,4-dichlorophenoxide 
• 32026-08-7 2-(3,4-dichlorophenoxy)acetamide 

Downstream Products

• 15422-26-1 N-(4-Chloro-phenyl)-2-(3,4-dichloro-phenoxy)-acetamide 
• 69764-13-2 2-({[(3,4-dichlorophenyl)oxy]acetyl}amino)benzoic acid 
• 69764-14-3 4-Chloro-2-[2-(3,4-dichloro-phenoxy)-acetylamino]-benzoic acid 
• 98919-01-8 (3,4-Dichloro-phenoxy)-acetic acid allyl ester 
• 1450833-01-8 2-(3,4-dichlorophenoxy)-N-(4-((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)butyl)acetamide 

Relevant articles and documents

NURR1 RECEPTOR MODULATORS

Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.

An Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is an important target for new bleaching herbicides discovery. As a continuous work to discover novel crop selective HPPD inhibitor, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using N,N′-carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH2Cl2. A total of 58 triketone compounds were synthesized in good to excellent yields. Some of the triketones displayed potent in vitro Arabidopsis thaliana HPPD (AtHPPD) inhibitory activity. 2-(2-((1-Bromonaphthalen-2-yl)oxy)acetyl)-3-hydroxycyclohex-2-en-1-one, II-13, displayed high, broad-spectrum, and postemergent herbicidal activity at the dosage of 37.5-150 g ai/ha, nearly as potent as mesotrione against some weeds. Furthermore, II-13 showed good crop safety against maize and canola at the rate of 150 g ai/ha, indicating that II-13 might have potential as a herbicide for weed control in maize and canola fields. II-13 is the first HPPD inhibitor showing good crop safety toward canola.

THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE

The present invention relates to substituted thiadiazole compounds of the formula (I) and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for modulating SCD activity.