58820-36-3

Usage

Uses

Used in Scientific Research:
1-(4-chloro-o-tolyl)piperazine is used as a research tool for studying [application reason] serotonin receptors and their functions in the central nervous system. It helps researchers understand the role of serotonin in various physiological and pathological processes.
Used in Pharmaceutical Development:
1-(4-chloro-o-tolyl)piperazine is used as a potential therapeutic agent for [application reason] the treatment of drug addiction and mood disorders, due to its interactions with neurotransmitter systems, including dopamine and norepinephrine.
Used in Neuropharmacology:
1-(4-chloro-o-tolyl)piperazine is used as a compound to investigate [application reason] the neuropharmacology of serotonin, particularly its interactions with the delta-opioid receptor and other neurotransmitter systems.

InChI:InChI=1/C11H15ClN2/c1-9-8-10(12)2-3-11(9)14-6-4-13-5-7-14/h2-3,8,13H,4-7H2,1H3

Upstream product

• 849106-83-8 4-(4-chloro-2-methyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 144-55-8 sodium hydrogencarbonate 
• 14495-51-3 2-bromo-5-chlorotoluene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 95-69-2 4-chloro-2-methylbenzeneamine 

Downstream Products

• 90125-99-8 1-(4-Chloro-2-methyl-phenyl)-4-(2-pyridin-2-yl-ethyl)-piperazine; compound with (E)-but-2-enedioic acid 

Relevant academic research and scientific papers

CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.

Practical method for parallel synthesis of diversely substituted 1-phenylpiperazines

A simple and practical method to prepare 'libraries' of substituted 1-phenylpiperazine building blocks in parallel format has been developed.

4-Aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators

Positive allosteric modulation of metabotropic glutamate receptor 5 (mGluR5) is regarded as a potential novel treatment for schizophrenic patients. Herein we report the synthesis and SAR of 4-aryl piperazine and piperidine amides as potent mGluR5 positive allosteric modulators (PAMs). Several analogs have excellent activity and desired drug-like properties. Compound 2b was further characterized as a PAM using several in vitro experiments, and produced robust activity in several preclinical animal models.

Chemokine receptor antagonists and methods of use thereof

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.

Tetracyclic benzimidazole derivatives and combinatorial libraries thereof

The present invention relates to novel tetracyclic benzimidazole derivative compounds of the following formula: wherein R1to R10have the meanings described in here. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing tetracyclic benzimidazole derivative compounds.

Isoxazolecarboxamide derivatives

The invention relates to novel N-(substituted phenyl)-N′-[ω-(3-substituted phenyl-4-isoxazolecarbonylamino)alkyl]piperazines, their N-oxides, and pharmaceutically acceptable salts thereof. The compounds are endowed with enhanced selectivity for alpha1-adrenergic receptors and a low activity in lowering blood pressure. The compounds are useful in the treatment of obstructive syndromes of the lower urinary tract, including benign prostatic hyperplasia (BPH), and in the treatment of lower urinary tract symptoms (LUTS) and neurogenic lower urinary tract dysfunction (NLUTD), and other conditions.