58836-98-9Relevant academic research and scientific papers
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain
Chiyanzu, Idan,Hansell, Elizabeth,Gut, Jiri,Rosenthal, Philip J.,McKerrow, James H.,Chibale, Kelly
, p. 3527 - 3530 (2003)
While commercial isatins were practically inactive against the target proteases, thiosemicarbazone derivatives were found to be active. The most active compound from the series displayed an inhibitory IC50 value of 1 μM against rhodesain. One thiosemicarbazone was found to be active against all three proteases with inhibitory IC50 values of 10 μM or less. A combination of N-benzylation and appropriate substitution on the aromatic portion of the isatin scaffold was generally found to be beneficial especially against cruzain for ketone inhibitors.
13C NMR Study of N-Acyl- and N-Sulphonyl-isatins and their Ring-Opened Derivatives
Angell, E. Charles,Black, David St C.,Kumar, Naresh
, p. 1 - 5 (2007/10/02)
The complete assignments of the 13C NMR resonances of 1-acetyl-, 1-benzoyl-, 1-benzenesulphonyl-, 1-methanesulphonyl- and 1-(2-nitrobenzenesulphonyl)-isatins and their ring-opened glyoxylic derivatives are reported.The 13C assignments of acylisatins were derived from isatin as a model, while assignments of glyoxylic derivatives were made by complete assignment of compound 8b together with its use as a model. KEY WORDS: 13C NMR, 1-Acyl-2,3-dihydroindole-2,3-diones, 2-Acylamidophenylglyoxylic acid derivatives
