58844-03-4Relevant academic research and scientific papers
One-pot synthesis of imidazopyridine derivatives
Parenty, Alexis D. C.,Cronin, Leroy
, p. 1479 - 1485 (2008/12/21)
Two highly efficient and general one-pot annulation reactions are described for the synthesis of imidazopyridine derivatives (IPs). The two procedures are complementary to each other: Whereas the first one allows the production of simpler IPs, the second
A general and efficient five-step one-pot procedure leading to nitrogen-bridgehead heterocycles containing an imidazole ring
Parenty, Alexis D. C.,Song, Yu-Fei,Richmond, Craig J.,Cronin, Leroy
, p. 2253 - 2256 (2008/02/04)
A very simple annulation reaction was designed, allowing an imidazole moiety to be fused onto a range of pyridine-based derivatives. The methodology consists of an activation step via the formation of a pyridinium salt to increase the electrophilicity of
An unusual substitution reaction directed by an intramolecular re-arrangement
Parenty, Alexis D.C.,Smith, Louise V.,Cronin, Leroy
, p. 8410 - 8418 (2007/10/03)
Secondary amines and thiols undertake a substitution reaction on the side chain of 2-bromoethyl-pyridinium derivatives 'directed' by an intramolecular re-arrangement. Experimental investigations strongly indicate that the reaction is initiated by an alpha
General one-pot, three-step methodology leading to an extended class of N-heterocyclic cations: Spontaneous nucleophilic addition, cyclization, and hydride loss
Parenty, Alexis D. C.,Smith, Louise V.,Pickering, Alexandra L.,Long, De-Liang,Cronin, Leroy
, p. 5934 - 5946 (2007/10/03)
A new class of phenanthridinium derivative has been isolated from the reaction of 2-bromoethyl-phenanthridinium bromide with a range of primary amines in excellent yields. The reaction pathway is unprecedented and proceeds via three cascade steps: nucleop
3-Halo-cepham derivatives
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, (2008/06/13)
Penicillin sulfoxides are converted to 3-halo-3-methyl-cepham-4-carboxylic acid esters and amides or the corresponding cephem derivatives by heating the penicillin sulfoxide precursor in a polyhaloalkane solvent to a temperature between 50° to about 150°C
