58861-61-3

Upstream product

• 1504-78-5 3-phenylquinoxaline-2(1H)-one 
• 5955-64-6 2-oxo-N,2-diphenylethanethioamide 
• 95-54-5 1,2-diamino-benzene 
• 7065-92-1 2-chloro-3-phenylquinoxaline 
• 23465-73-8 3-Phenyl-1,2,3,4-tetrahydroquinoxalin-2-one 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 

Downstream Products

• 95155-75-2 methyl 3-mercapto-2-methyl-2-(3-phenylquinoxalin-2-yl)propanoate 
• 95155-72-9 3-mercapto-2-methyl-2-(3-phenylquinoxalin-2-yl)propanenitrile 
• 95155-69-4 2-(3-phenylquinoxalin-2-yl)cyclohexane-1-thiol 
• 912363-53-2 2-ethoxycarbonylmethylthio-3-phenylquinoxaline 
• 912363-03-2 2-(N-phenylcarbamoylmethylthio)-3-phenylquinoxaline 
• 912363-09-8 2-(3-phenyl-quinoxalin-2-ylsulfanyl)-N-p-tolyl-acetamide 
• 912363-05-4 N-(4-chloro-phenyl)-2-(3-phenyl-quinoxalin-2-ylsulfanyl)-acetamide 
• 128381-36-2 (3-phenyl-2-quinoxalylthio)phenylacetic acid 
• 128381-33-9 (3-phenyl-2-quinoxalyl)thioacetic acid 
• 78677-14-2 3-methylthio-2-phenyl-1,4-quinoxaline 
• 100463-04-5 C₂₂H₁₄N₂OS 
• 128381-38-4 C₁₆H₁₀N₂OS 

Relevant academic research and scientific papers

A novel method for heterocyclic amide-thioamide transformations

In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61°C to afford heteocyclic thioamides in excellent yields.

Synthesis and in vitro-anticancer and antimicrobial evaluation of some novel quinoxalines derived from 3-phenylquinoxaline-2(1 H)-thione

Two novel series derived from 3-phenylquinoxaline-2(1H)-thione 2 and 2-(hydrazinocarbonylmethylthio)-3-phenylquinoxaline 6 have been synthesized. Eight out of twenty six new compounds were selected at the National Cancer Institute for evaluation of their

Electrophilic cyanations. I. Synthesis of thiocyanato-heteroarenes and tosylheteroarenes from mercapto-heteroarenes using p-toluenesulfonyl cyanide

Mercaptoheteroarenes (1) underwent electrophilic cyanation with p-toluenesulfonyl cyanide (TsCN) in THF in the presence of NaH to give the corresponding thiocyanatoheteroarenes (2) in moderate to good yields. In DMF, tosylheteroarenes (4) were formed by substitution with p-toluenesulfinate ion through thiocyanatoheteroarenes (2).

Photocycloaddition of Quinoxaline-2(1H)-thiones to Alkenes

A synthetically useful C-C bond formation involving the photochemical addition of quinoxaline-2(1H)-thiones to alkenes is described.Irradiation of the quinoxaline-2(1H)-thiones 1-4 in the presence of the alkenes 7 gave the 2-(2'-mercaptoalkyl)quinoxalines 8-11 in moderate-to-good yields via ring cleavage of an intermediate aminothietane with aromatization of the quinoxaline ring.The latter was formed by photocycloaddition of the C=S bond of the quinoxaline-2(1H)-thione and the C=C bond of the alkene.

SYNTHESIS AND REACTIONS OF 3-PHENYL-3,4-DIHYDRO-1,4-QUINOXALIN-2(1H)-ONE AND ITS HETEROCYCLIC ANALOGUES

The lactams quinoxalinone 3a, benzothiazinone 3b and benzothiazinone 3c were synthesized by reactions of methyl 2-bromo-2-phenylethanoate 1 with orthosubstituted arylamines 2a-2c.Subsequent reductive alkylation of the lactams with sodium hydride and iodom