588731-93-5Relevant academic research and scientific papers
Lewis base activation of Lewis acids. Vinylogous aldol reactions
Denmark, Scott E.,Beutner, Gregory L.
, p. 7800 - 7801 (2003)
A highly regioselective vinylogous aldol reaction catalyzed by SiCl4 and a chiral phosphoramide (R,R)-5, providing δ-hydroxy enones for a variety of aldehyde and dienol ether structures, has been developed. Low catalyst loadings (1 mol %) can b
Lewis base activation of Lewis acids: Catalytic, enantioselective addition of silyl ketene acetals to aldehydes
Denmark, Scott E.,Beutner, Gregory L.,Wynn, Thomas,Eastgate, Martin D.
, p. 3774 - 3789 (2007/10/03)
The concept of Lewis base activation of Lewis acids has been reduced to practice for catalysis of the aldol reaction of silyl ketene acetals and silyl dienol ethers with aldehydes. The weakly acidic species, silicon tetrachloride (SiCl4), can b
