58888-41-8

Upstream product

• 108-05-4 vinyl acetate 
• 134254-23-2 mephenesin 
• 2186-24-5 cresyl-glicidyl ether 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

Zeolite catalyzed ring opening of epoxides to acetylated diols with acetic anhydride

HY Zeolite is found to be a versatile catalyst for opening of epoxides to the corresponding acetylated 1,2-Diols with acetic anhydride in good yields.

Kinetic resolution of acyclic 1,2-diols using a sequential lipase- catalyzed transesterification in organic solvents

A method for the kinetic resolution of 3-(aryloxy)-1,2-propanediols rac- 1a-n without additional protection-deprotection steps using a lipase- catalyzed sequential transesterification with lipase amano PS has been developed. In the first step of this one-pot procedure the racemic 1,2-diols are acylated regioselectively at the primary hydroxy group without enantioselection. The subsequent acylation at the secondary hydroxy group of the formed primary monoacetate is responsible for high enantioselection. The enantioselectivity of this transformation depends significantly on the substitution pattern of the aryl ring and the organic solvent used. 3- (Aryloxy)-1,2-propanediols with substituents in the para-position show a much higher enantioselectivity than the corresponding derivatives with ortho- substituents. Among other substrates, the pharmaceuticals Mephenesin, Guaifenesin, and Chlorphenesin have been resolved. The replacement of the aryloxy by an alkyl substituent causes a dramatic decrease of enantioselectivity.

Kinetic resolution of aliphatic 1,2-diols by a lipase-catalyzed sequential acetylation

The kinetic resolution of 13 racemic aliphatic 1,2-diols (rac-1a-m) by means of a lipase-catalyzed sequential acetylation was investigated. The enantioselectivity of the 3-aryloxy-propane-1,2-diols rac-1a-k depends on the substitution pattern at the aryl ring.