58888-87-2Relevant articles and documents
Discovery of begacestat, a Notch-1-sparing γ-secretase inhibitor for the treatment of Alzheimer's disease
Mayer, Scott C.,Kreft, Anthony F.,Harrison, Boyd,Abou-Gharbia, Magid,Antane, Madelene,Aschmies, Suzan,Atchison, Kevin,Chlenov, Michael,Cole, Derek C.,Comery, Thomas,Diamantidis, George,Ellingboe, John,Fan, Kristi,Galante, Rocco,Gonzales, Cathleen,Ho, Douglas M.,Hoke, Molly E.,Hu, Yun,Huryn, Donna,Jain, Uday,Jin, Mei,Kremer, Kenneth,Kubrak, Dennis,Lin, Melissa,Lu, Peimin,Magolda, Ron,Martone, Robert,Moore, William,Oganesian, Aram,Pangalos, Menelas N.,Porte, Alex,Reinhart, Peter,Resnick, Lynn,Riddell, David R.,Sonnenberg-Reines, June,Stock, Joseph R.,Sun, Shaiu-Ching,Wagner, Erik,Wang, Ting,Woller, Kevin,Xu, Zheng,Zaleska, Margaret M.,Zeldis, Joseph,Zhang, Minsheng,Zhou, Hua,Jacobsen, J. Steven
supporting information; experimental part, p. 7348 - 7351 (2009/12/23)
SAR on HTS hits 1 and 2 led to the potent, Notch-1-sparing GSI 9, which lowered brain Aβ in Tg2576 mice at 100 mg/kg po. Converting the metabolically labile methyl groups in 9 to trifluoromethyl groups afforded the more stable analogue 10, which had impro
USE OF TETRAETHYL DIMETHYLAMINOMETHYLENEDIPHOSPHONATE IN THE SYNTHESIS OF BENZOTHIOPHENE-2-ACETIC ACID AND OTHER CARBOXYLIC ACIDS
Degenhardt, Charles R.
, p. 415 - 422 (2007/10/02)
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