58901-12-5Relevant articles and documents
Preparation method of hydroxyl tertiary amine hydrochloride crystal
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Paragraph 0083; 0084; 0085; 0086, (2021/03/24)
The invention discloses a preparation method of a hydroxyl tertiary amine hydrochloride crystal. The preparation method comprises the following steps of: (1) dissolving hydrochloric acid in lower alcohol to form a hydrochloric acid alcohol solution; (2) adding the hydrochloric acid alcohol solution in the step (1) and hydroxyl tertiary amine into a reactor, and reacting under the N2 protection condition to obtain a hydroxyl tertiary amine hydrochloride primary product; and (3) heating and dissolving the hydroxyl tertiary amine hydrochloride primary product obtained in the step (2) by using anorganic solvent, decolorizing, cooling, crystallizing, separating the crystallized precipitate, and drying to obtain the hydroxyl tertiary amine hydrochloride crystal. The hydroxyl tertiary amine hydrochloride crystal prepared by the method has a high dissolution rate in water and can be accurately metered, and the accuracy of the hydroxyl tertiary amine hydrochloride crystal used for compoundingadditives is improved. As a crystal, compared with liquid, solid quantitative packaging can be adopted, and the packaging cost, the transportation cost and the storage cost are all reduced. The methodhas the advantages of few steps, simple separation of the intermediate product, easy operation of the crystallization purification method, and low production cost.