58901-88-5Relevant academic research and scientific papers
Zinc chloride catalyzed ring opening of 3-mono- and 3,3-disubstituted glycidonitriles by means of acetyl chloride
Zdrojewski,Fedorynski,Jonczyk
, p. 941 - 946 (2007/10/03)
Glycidonitriles 1a-e, when treated with acetyl chloride in the presence of catalytic amounts of zinc chloride, afforded mixtures of chloroacetoxynitriles 2 and acetoxycyanoalkenes 4. Isolated nitriles 2 treated with triethylamine transform into substituted acetoxyacrylonitriles 3.
Preparing carboxylic acids from glycidonitriles through enol acylates
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, (2008/06/13)
Process for preparing carboxylic acids by converting a glycidonitrile to the enol acylate via hydrohalogenation, acylation and dehydrohalogenation procedures, and conversion of the enol acylate to the carboxylate salt with a base and of the salt to the carboxylic acid with acid. Cyanide content in the mixture is destroyed by adding persulfate or hypochlorite salts. This process, can be used, e.g., to prepare 2-(4'-isobutylphenyl)propionic acid, now known generically as ibuprofen, a highly active anti-inflammatory drug, as well as a host of other useful carboxylic acids.
