36929-66-5

Usage

Uses

Used in Pharmaceutical Industry:
1-Oxaspiro[2.5]octane-2-carbonitrile is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique spiro ring structure contributes to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
1-Oxaspiro[2.5]octane-2-carbonitrile is used as a building block in the creation of agrochemicals, such as pesticides and herbicides. Its structural properties may enhance the effectiveness of these chemicals in agricultural settings.
Used in Chemical Research:
1-Oxaspiro[2.5]octane-2-carbonitrile serves as a subject of study in chemical research, where its properties and potential applications are explored. This may lead to a better understanding of its role in the synthesis of complex molecules and its potential uses in various industries.

Upstream product

• 108-94-1 cyclohexanone 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 1192-88-7 1-cyclohexene-1-carboxaldehyde 
• 57230-08-7 1-amino-2-cyclohexylethan-2-ol 
• 58901-87-4 1-Hydroxy-1-<1-chlor-cyclohexyl-(1)>-acetonitril 
• 39884-50-9 1-(2-aminoethyl)cyclohexanol 
• 91012-10-1 1-(acetoxycyanomethyl)cyclohexene 
• 15419-46-2 1-formylcyclohexene 2,4-dinitrophenylhydrazone 
• 24446-49-9 <2-Acetylamino-1-hydroxy-aethyl-(1)>-cyclohexan 
• 102450-93-1 1-Hydroxy-1-<2-acetylamino-aethyl-(1)>-cyclohexan 
• 79224-37-6 1-Hydroxy-1-<1-hydroxy-cyclohexyl-(1)>-acetonitril 
• 53627-10-4 1-chlorocyclohexane-1-carbaldehyde 
• 117169-36-5 <(5E,Z),(13E)>-15-(1-Fluorocyclohexyl)-11α,(15R)-dihydroxy-ω-pentanor-9a-carbaprostacyclin 
• 117169-36-5 <(5E,Z),(13E)>-15-(1-Fluorocyclohexyl)-11α,(15S)-dihydroxy-ω-pentanor-9a-carbaprostacyclin 
• 117169-35-4 1-exo-<3-(1-Fluorocyclohexyl)-3(R)-hydroxy-(E)-1-propenyl>-2-endo-hydroxy-5-oxooctahydropentalene 
• 117169-35-4 1-exo-<3-(1-Fluorocyclohexyl)-3(S)-hydroxy-(E)-1-propenyl>-2-endo-hydroxy-5-oxooctahydropentalene 

Relevant academic research and scientific papers

ALPHA-HYDROXY-BETA-AZIDO-TETRAZOLES

Alpha-hydroxy-beta-azido tetrazole compounds of formula (I): a process for manufacturing alpha-hydroxy-beta-azido tetrazoles of formula (I), and their use for synthesizing new compounds, e.g. in “click” chemistry.

Expedient synthesis of glycidonitriles by darzens condensation of α-halogenonitriles with aldehydes and ketones

Chloroacetonitrile (1), α-halogenopropionitriles 4, and α-chlorophenylacetonitrile (6) react with aldehydes 2a,b,h-o and ketones 2c-g,p-t in the presence of solid NaOH in THF or DME, without any added catalyst, affording substituted glycidonitriles 3a-t, 5a, c-g,r,s and 7a,b,i,j,u,v, respectively (Darzens condensation). The glycidonitriles 3a-h, prepared from 1 and carbonyl compounds 2a-h, are obtained in high yields, exceeding those reported in the literature (Table 5). Expedient results of the reactions studied are due to increased reactivity of anions with Na+ as counterion in ethereal solvents. Investigation of the concentration of NaOH and the carbanion of diphenylacetonitrile in selected solvents reveals that ethereal solvents may increase the solubility of the anions participating in Darzens condensation.

Quaternary ammonium salts used as phase transfer catalyst

Novel quaternary ammonium salts of general formula (I) STR1 wherein: R is a saturated or unsaturated, linear or branched alkyl radical of C1 to C8. R' is a saturated or unsaturated, linear or branched alkyl radical of C1 to C12, or a benzyl radical. n is a number equal to 2 or 3. Xθ is a halogenide anion, such as Clθ, Brθ, Iθ, are used as phase transfer catalysts, in heterogeneous ionic reactions wherein the reagents are in different phase and have different polarity.

NEW SYNTHETIC ROUTES TO β-FLUORO β-PHENYLLACTIC ACID DERIVATIVES AND Β-FLUOROCYANOHYDRINS

Alkyl phenyl 2,3-epoxycarboxylates from the well-known Darzens glycidic esters synthesis react under very mild conditions with pyridinium-poly-hydrogen fluoride to give corresponding 3-fluoro 3-phenyllactates in almost quantitative yields with a high regio and stereoselectivity.This method can be applied succesfully to other flycidic derivatives: glycidoamides, glycidonitriles, glycidoiminoesters...The spectrometric properties (IR, NMR) are presented.

NOUVELLE VOIE DE SYNTHESE D'ACIDES AMINES MONOFLUORES

Ring opening of the glycidonitriles (IIa-e) by HF/pyridine leads to the fluorocyanohydrins (IIIa-e).Treatment of the nitriles (IIIa-e) with ammonia in methanol gives the α-amino-β-fluoro nitriles (IVa-e) which upon acidic hydrolysis afford the β-fluoro-α-

Two-phase Darzens Condensation Reaction with Octopus Compounds as a Catalyst

The octopus compound, readily derived from hexakis(mercaptomethyl)benzene and 1-chloro-3,6,9-triozadecane, was effectively employed as a catalyst in the two-phase Darzens condensation of carbonyl compounds with chloroacetonitrile to afford the correspondi