58905-26-3

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-phenyl-2-(1H-1,2,4-triazol-1-yl)is utilized as a building block in the synthesis of pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs, contributing to advancements in medicine.
Used in Agricultural Industry:
In agriculture, Ethanone, 1-phenyl-2-(1H-1,2,4-triazol-1-yl)may have potential applications as an antifungal, antiviral, or antiparasitic agent. Its biological activities can be harnessed to protect crops and enhance agricultural productivity.
Used in Research:
Ethanone, 1-phenyl-2-(1H-1,2,4-triazol-1-yl)also serves as a research tool in biochemical studies. Its properties and interactions with other compounds can provide valuable insights into various biological processes and contribute to the understanding of complex chemical reactions.
Overall, Ethanone, 1-phenyl-2-(1H-1,2,4-triazol-1-yl)is a versatile chemical compound with significant applications across different industries, making it an important substance for ongoing research and development.

Upstream product

• 288-88-0 1,2,4-Triazole 
• 70-11-1 α-bromoacetophenone 
• 532-27-4 1-chloroacetophenone 
• 71-43-2 benzene 
• 98-86-2 acetophenone 
• 1092852-28-2 1-phenyl-2-(1,2,4-1H-triazol-1-yl)ethanone hydrochloride 
• 118227-29-5 4-Amino-1-(2-oxo-2-phenyl-ethyl)-4H-[1,2,4]triazol-1-ium; chloride 
• 120669-94-5 4-Phenacyl-1,2,4-triazole 

Downstream Products

• 133593-03-0 (1-N-phenacyl-4-N-carbethoxymethylene)-1,2,4-triazolium bromide 
• 99736-87-5 3-(4-chlorophenyl)-1-phenyl-2-(1H-1,2,4-triazol-1-yl)-propen-1-one 
• 241146-78-1 (E)-3-Dimethylamino-1-phenyl-2-[1,2,4]triazol-1-yl-propenone 
• 168009-80-1 1-(2-phenyl-oxiranylmethyl)-1H-[1,2,4]triazole 
• 877875-94-0 N-[4-phenyl-5-(1,2,4-triazol-1-yl)thiazol-2-yl]amide 
• 64921-72-8 1-phenyl-2-(1H-1,2,4-triazol-1-yl)ethanone oxime 
• 953906-04-2 C₁₀H₁₂N₄ 
• 1206880-86-5 N-[1-phenyl-2-(1H-1,2,4-triazol-1-yl)ethylidene]-N'-phenylhydrazine 
• 1206880-95-6 2-phenyl-3-(1H-1,2,4-triazol-1-yl)-1H-indole 
• 1278594-45-8 2-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenyl-5-(1H-1,2,4-triazol-1-yl)-thiazole 
• 1278594-48-1 C₂₆H₁₉ClN₆S 

Relevant academic research and scientific papers

Asymmetric transfer hydrogenation of heterocycle-containing acetophenone derivatives using N-functionalised [(benzene)Ru(II)(TsDPEN)] complexes

The application of enantiomerically-pure ruthenium(II) catalysts containing N - functionalised TsDPEN ligand to the asymmetric transfer hydrogenation of 15 examples of α-heterocyclic acetophenone derivatives is reported. Products of up to 99% ee were formed.

Novel triazole-containing allyl ether compound as well as preparation method and application thereof

The invention discloses a novel triazole-containing allyl ether compound as well as a preparation method and application thereof. The structural formula of the novel triazole-containing allyl ether compound is shown as a formula (I), in the formula (I), R

Novel triazole-containing allyl benzoic acid ester compound as well as preparation method and application thereof

The invention discloses a novel triazole-containing allyl benzoic acid ester compound as well as a preparation method and application thereof. The structural formula of the novel triazole-containing allyl benzoic acid ester compound is shown as a formula

A one-pot multicomponent ‘click’ approach to the synthesis of novel tamoxifen-triazole conjugates using nano iron oxide catalyst and their preliminary antiproliferative activity studies

Background: In an effort to establish new drug candidates with improved antiproliferative activity, we report here a novel class of compounds designed rationally by the replacement of an ethyl group in tamoxifen with a methylene (1H-1,2,4-triazole) and th

Synthesis and Biological Evaluation of Novel Triazole Derivatives as Strigolactone Biosynthesis Inhibitors

Strigolactones (SLs) are one of the plant hormones that control several important agronomic traits, such as shoot branching, leaf senescence, and stress tolerance. Manipulation of the SL biosynthesis can increase the crop yield. We previously reported tha

Method for synthesizing thiazole derivative containing acetophenone triazole group in ultrasonic solvent-free manner

The invention relates to a method for synthesizing a thiazole derivative containing an acetophenone triazole group in an ultrasonic solvent-free manner. Three solids of alpha-(1H-1,2,4-triazol-1-yl)acetophenone, phenyl isothiocyanate and potassium hydroxi

Design, synthesis, & biological activity of new triazole & nitro-triazole derivatives as antifungal agents

In this study two series of fluconazole derivatives bearing nitrotriazole (series A) or piperazine ethanol (series B) side chain were designed and synthesized and then docked in the active site of lanosterol 14α-demethylase enzyme (1EA1) using the Autodock 4.2 program (The scripps research institute, La Jolla, CA, USA). The structures of synthesized compound were confirmed by various methods including elemental and spectral (NMR, CHN, and Mass) analyses. Then antifungal activities of the synthesized compound were tested against several natural and clinical strains of fungi using a broth microdilution assay against several standard and clinical fungi. Nitrotriazole derivatives showed excellent and desirable antifungal activity against most of the tested fungi. Among the synthesized compounds, 5a-d and 5g, possessing nitrotriazole moiety, showed maximum antifungal activity, in particular against several fluconazole-resistant fungi.

Synthesis and Antimicrobial Activity of Novel 2-Substituted Phenoxy-N-(4-substituted Phenyl-5-(1H-1,2,4-triazol-1-yl)thiazol-2-yl)acetamide Derivatives

A series of 2-substituted phenoxy-N-(4-substituted phenyl-5-(1H-1,2,4-triazol-1-yl)thiazole-2-yl)acetamide derivatives 8a, 8b, 8c, 8d, 8e, 8f, 8g, 8h, 8i, 8j, 8k, 8l, 8m, 8n, 8o, 8p, 8q, 8r, 8s, 8t was synthesized by the reaction of phenoxyacetyl chloride 7 with intermediate 4-substituted phenyl-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amine 5. Their structures were confirmed by 1H NMR, 13C NMR, MS, IR, and elemental analyses. The synthesized compounds were also screened for their antimicrobial activity against three types of plant fungi (Gibberella zeae, Phytophthora infestans, and Paralepetopsis sasakii) and two kinds of bacteria [Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac)] showing promising results. In particular, 8b, 8f, 8g, and 8h exhibited excellent antibacterial activity against Xoo, with 50% effective concentration (EC50) values of 35.2, 80.1, 62.5, and 82.1 μg/mL, respectively, which are superior to the commercial antibacterial agent bismerthiazol (89.9 μg/mL). The preliminary structure–activity relationship studies of these compounds are also briefly described.

Catalytic asymmetric synthesis of β-triazolyl amino alcohols by asymmetric transfer hydrogenation of α-triazolyl amino alkanones

The synthesis of optically active β-triazolyl amino alcohols was carried out via ruthenium catalyzed asymmetric transfer hydrogenation of α-triazolyl amino alkanones. This reaction proceeds under mild reaction conditions with up to 99% yield and 99.9% ena

Triazole acetylene compound and application thereof

The invention discloses a triazole acetylene compound shown in the general formula I (please see the formula I in the description). R1 is alkyl, aryl and heteroaryl; R2 is H, halogen, CN, NO2, alkyl, halogenated alkyl, alkoxy and alkylthiol. The compound of the general formula I has excellent fungicidal activity and can be used for preventing and treating diseases.