58913-46-5

Usage

Uses

Used in Pharmaceutical Industry:
6,6-dimethyl-4-(phenylamino)-5,6-dihydropyridine-2(1H)-thione is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential biological and pharmacological activities.
Used in Cardiovascular Applications:
In the pharmaceutical industry, 6,6-dimethyl-4-(phenylamino)-5,6-dihydropyridine-2(1H)-thione is used as an active pharmaceutical ingredient for the development of antihypertensive and calcium channel blocker drugs. Its unique structure and properties contribute to its ability to regulate blood pressure and improve cardiovascular health.
Used in Drug Discovery and Research:
6,6-dimethyl-4-(phenylamino)-5,6-dihydropyridine-2(1H)-thione is utilized as a research compound in drug discovery and development. Its potential biological activities make it a valuable tool for studying the mechanisms of action and therapeutic effects of new drug candidates in the field of medicine and pharmaceuticals.

Upstream product

• 16325-43-2 1-phenyl-4,4,6-trimethyl-1,4-dihydropyrimidine-2(3H)thione 
• 58913-37-4 4-methylamino-6,6-dimethyl-5,6-dihydropyridine-2(1H)-thione 
• 62-53-3 aniline 
• 59743-23-6 4-(dimethylamino)-5,6-dihydro-6,6-dimethyl-2(1H)-pyridinthione 
• 62432-97-7 5,6-dihydro-6,6-dimethyl-4-(1-morpholinyl)pyridine-2(1H)-thione 
• 77747-75-2 4-(3-Diethylamino-propylamino)-6,6-dimethyl-5,6-dihydro-1H-pyridine-2-thione 
• 58913-45-4 4-benzylamino-6,6-dimethyl-5,6-dihydro-1H-pyridine-2-thione 
• 77747-74-1 4-Aminodihydro-2(1H)-pyridinthion 
• 77747-72-9 5,6-Dihydro-4-hydroxy-6,6-dimethyl-2(1H)-pyridinthion 

Downstream Products

• 58913-45-4 4-benzylamino-6,6-dimethyl-5,6-dihydro-1H-pyridine-2-thione 

Relevant academic research and scientific papers

Synthesis of new tetrahydropyridinylidene ammonium salts and their antiprotozoal potency

Several new tetrahydropyridinylidene ammonium salts were prepared by selective reduction. They were characterized using UV-Vis spectroscopy, FT-IR spectroscopy, and HRMS. Their structure was established by NMR spectroscopy and a single X-ray structure ana

Thermally induced transformations of 1-substituted-4,4,6-trimethyl-1,4-dihydropyrimidine-2(3H)-thiones

Intramolecular thermal rearrangement of 1-substituted-4,4,6-trimethyl-1,4-dihydropyrimidine-2(3H)-thiones (1) to 4-substituted-amino-6,6-dimethyl-5,6-dihydropyridine-2(1H)-thiones (2), in molten state, constituting a unique Dimroth type rearrangement is reported.

4-Hydroxy-6,6-dimethyl-5,6-dihydro-2(1H)-pyridinethione and -one and the Corresponding Tautomers

The tautomers, 4-hydroxy-5,6-dihydro-6,6-dimethyl-2(1H)-pyridinethione (1) and 6,6-dimethyl-2-thioxo-4-piperidone (2) resp., and 4-hydroxy-5,6-dihydro-6,6-dimethyl-2(1H)-pyridone (9) and 6,6-dimethyl-2,4-piperidinedione (10) resp. were synthesized by hydrolysis of 4-amino-5,6-dihydro-6,6-dimethyl-2(1H)-pyridinethiones (4,5) and -ones (11,12). 1,2 and 9,10 undergo an aminolysis in amines to the corresponding 4-aminodihydro-2(1H)-pyridinethiones 4,5 and -ones 11, 12 resp. - Keywords: 6,6-Dimethyl-2,4-piperidindione; 6,6-Dimethyl-2-thioxo-4-piperidone; 4-Hydroxy-6,6-dimethyl-5,6-dihydro-2(1H)-pyridone, and -pyridinethione; Keto-enol-tautomeris m

2,4-Diaminodihydropyridines (Heterocyclic Compounds, 67. Comm.)

Aminolysis of 4-alkylamino- and 4-dialkylamino-2-methylthiodihydropyridines (*Hl) 1, 2 resp. under various reaction-condition leads to assymmetrically or symmetrically substituted 2,4-bisalkylamino- or 2,4-bisdialkylamino- and 2-alkylamino-4-dialkylamino- or 2-dialkylamino-4-alkylaminodihydropyridines 3, 4, 5, 6 resp.On treatment with alkali only the aminogroup in pos.4 of the pyridines 3, 4, 5, 6 is hydrolyzed and 4-hydroxy-2-aminopyridines 9 are formed.Different substituted 2,4-diaminodihydropyridines 3, 4, 5, 6 can also be synthesized by reaction of 4-hydroxy-2-aminopyridines (*HCl) 9 with amines.Also the aminolysis of 4-alkylamino- and 4-dialkylaminodihydropyridinthiones 7, 8 resp. is described. - Keywords: 2-Alkylamino-4-dialkylamino-5,6-dihydropyridines, synthesis; Alkyl- and arylaminopyridine derivatives, reaction with prim. and sec. amines; Aminolysis of alkyl-, and arylaminopyridine derivatives; 2,4-Bisalkylamino-5,6-dihydropyridines, synthesis; 2,4-Bisdialkylamino-5,6-dihydropyridines, synthesis; 2-Dialkylamino-4-alkylamino-5,6-pyridines, synthesis.