58928-28-2

Basic information

• Product Name: 2-(TRIFLUOROMETHYL)PROPIONALDEHYDE
• Synonyms: 2-(TRIFLUOROMETHYL)PROPIONALDEHYDE;2-(Trifluoromethyl)propionaldehyde 98%;2-(Trifluoromethyl)propionaldehyde98%;2-(Trifluoromethyl)propanal;2-Methyl-3,3,3-trifluoropropanal 98%;2-(Trifluoromethyl)propanal, 2-(Trifluoromethyl)propionaldehyde, 2-Methyl-3,3,3-trifluoropropaldehyde
• CAS NO: 58928-28-2
• Molecular Formula: C₄H₅F₃O
• Molecular Weight: 126.08
• Mol File: 58928-28-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 60°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 315mmHg at 25°C
• Refractive Index: 1.313
• CAS DataBase Reference: 2-(TRIFLUOROMETHYL)PROPIONALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TRIFLUOROMETHYL)PROPIONALDEHYDE(58928-28-2)
• EPA Substance Registry System: 2-(TRIFLUOROMETHYL)PROPIONALDEHYDE(58928-28-2)

Safety Data

• Hazard Codes: F
• Statements: 10
• Safety Statements: 16
• RIDADR: 1989
• Hazardous Substances Data: 58928-28-2(Hazardous Substances Data)

Usage

General Description

2-(Trifluoromethyl)propionaldehyde is a chemical compound with the molecular formula C4H5F3O. It is a colorless liquid with a pungent odor, commonly used in the production of pharmaceuticals and agrochemicals. 2-(TRIFLUOROMETHYL)PROPIONALDEHYDE is also used as an intermediate in the manufacturing of various chemical products, such as agrochemicals, fragrances, and flavors. Additionally, it is utilized as a building block for the synthesis of other organic compounds. Its trifluoromethyl group makes it a valuable reagent in organic synthesis, enabling the introduction of trifluoromethyl functionality into various chemical structures. Overall, 2-(Trifluoromethyl)propionaldehyde is an important chemical compound with wide-ranging applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C4H5F3O/c1-3(2-8)4(5,6)7/h2-3H,1H3

Upstream product

• 677-21-4 1,1,1-trifluoropropylene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 88486-65-1 3,3,3-trifluoro-2-methyl-1-phenylpropan-1-ol 
• 81619-01-4 C₁₃H₁₂F₃NO₃ 
• 381-97-5 (2RS)-3,3,3-trifluoro-2-methylpropanoic acid 
• 81328-26-9 2-phenyl-4-<2-(trifluoromethyl)propylidene>-5-oxazolone 
• 81328-25-8 2-phenyl-4-<2-(trifluoromethyl)propylidene>-5-oxazolone 

Relevant articles and documents

3-(PERFLUOROALKYL)PROPANAL PRODUCTION METHOD

PROBLEM TO BE SOLVED: To provide a method of producing 3-(perfluoroalkyl)propanal with high selectivity, which is an important compound as a fluorine-containing building block for drug and functional material synthesis. SOLUTION: (Perfluoroalkyl)ethylene represented by the general formula (2) is reacted with carbon monoxide and hydrogen in the presence of a rhodium compound and diphosphine to produce 3-(perfluoroalkyl)propanal represented by the general formula (3). (In the formulas, Rf represents the same C1-16 perfluoroalkyl group.) COPYRIGHT: (C)2015,JPOandINPIT

Studies on the preparation of 2-(trifluoromethyl)acrylic acid and its esters from 3,3,3-trifluoropropene via hydrocarbonylation reactions

The synthesis of methyl α-(trifluoromethyl)acrylate (MTFMA) has been carried out in three steps starting from commercially available 3,3,3,-trifluoropropene; this route involving the cobalt-catalyzed carbonylation of 2-bromo-3,3,3-trifluoropropene (2-Br-TFP) under very mild reaction conditions, gave only about 30% yield of the desired methyl ester. 2-(Trifluoromethyl)propanal, available in 90% yield by rhodium catalyzed hydroformylation of 3,3,3-trifluoropropene, proved to be an interesting starting product for the preparation of MTFMA: while the synthetic route involving the α-halogenation of 2-(trifluoromethyl)propanoic acid (TFMPA) failed to give any results, the reaction scheme based on the α-selenenylation of the above aldehyde followed by H2O2-oxidation afforded 68% yield of 2-(trifluoromethyl)acrylic acid (TFMAA).

Remarkable Dependency of Regioselectivity on the Catalyst Metal Species in the Hydroformylation of Trifluoropropene and Pentafluorostyrene

-