58934-46-6 Usage
Uses
Used in Pharmaceutical Industry:
Lorcainide hydrochloride is used as a cardiac depressant for the treatment of arrhythmias. It works by blocking the voltage-gated Na+ channels, which slows down the rate of depolarization and prolongs the refractory period of cardiac cells. This action helps to restore normal heart rhythm and prevent the occurrence of abnormal heart beats.
Used in Research Applications:
Lorcainide hydrochloride is also used as a research tool in the study of ion channels and their role in various physiological and pathological processes. It can be used to investigate the mechanisms of action of other Na+ channel blockers and to explore the potential therapeutic applications of these compounds in the treatment of various diseases, such as epilepsy, neuropathic pain, and certain types of cancer.
References
1) Sheldon?et al.?(1989),?Antiarrhythmic drugs and the cardiac sodium channel: current models; Clin. Chem.,?35?748
2) Lynch?et al.?(1995),?Sodium channel clockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists; J. Pharmacol. Exp. Ther.,?273?554
3) Almotrefi?et al. (1999),?Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase; Can. J. Physiol. Pharmacol.,?77?866
Check Digit Verification of cas no
The CAS Registry Mumber 58934-46-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,9,3 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 58934-46:
(7*5)+(6*8)+(5*9)+(4*3)+(3*4)+(2*4)+(1*6)=166
166 % 10 = 6
So 58934-46-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H27ClN2O.ClH/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-20)22(26)16-18-6-4-3-5-7-18;/h3-11,17,21H,12-16H2,1-2H3;1H
58934-46-6Relevant academic research and scientific papers
N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides
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, (2008/06/13)
Novel N-aryl-N-(1-L-4-piperidinyl)arylacetamides useful as anti-arrhythmic agents, a method of treating arrhythmia which comprises the systemic administration of such compounds to warm-blooded animals and pharmaceutical compositions to be used therefor.
N-aryl-N-(1-alkyl-4-piperidinyl)-arylacetamides
-
, (2008/06/13)
Novel N-aryl-N-(1-L-4-piperidinyl)arylacetamides useful as antiarrhythmic agents, a method of treating arrhythmia which comprises the systemic administration of such compounds to warm-blooded animals and pharmaceutical compositions to be used therefor.
