58952-14-0

Usage

Uses

Used in Organic Synthesis:
3,4-DIMETHOXY-THIOBENZAMIDE is used as a building block in organic synthesis for the creation of new compounds. Its unique structure allows it to participate in a variety of chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Research and Pharmaceutical Applications:
3,4-DIMETHOXY-THIOBENZAMIDE is used as a research compound for exploring its potential therapeutic properties. Its presence in pharmaceutical applications is due to the possibility of it being a precursor to drugs with medicinal benefits.
Used in Industrial Applications:
While the specific industrial uses of 3,4-DIMETHOXY-THIOBENZAMIDE are not fully detailed in the provided materials, it is mentioned that the compound may have other industrial applications. Further research is needed to fully understand and explore its potential uses in various industries.

InChI:InChI=1/C9H11NO2S/c1-11-7-4-3-6(9(10)13)5-8(7)12-2/h3-5H,1-2H3,(H2,10,13)

Upstream product

• 2024-83-1 veratronitrile 
• 62-55-5 thioacetamide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 2169-98-4 3,4-Dimethoxy-benzaldehyde oxime 
• 91-16-7 1,2-dimethoxybenzene 
• 333-20-0 potassium thioacyanate 
• 76195-87-4 N-isoquinolinio-3,4-dimethoxy(thiobenzamidate) 

Downstream Products

• 25020-89-7 2-(3,4-dimethoxy-phenyl)-5-methyl-4-phenyl-thiazole 
• 115540-91-5 2-(3,4-dimethoxyphenyl)-4-(2'-pyrazinyl)thiazole 
• 95642-51-6 2-(3,4-Dimethoxyphenyl)-4-hydroxy-6-oxo-1,3-thiazine 
• 145737-11-7 6-[2-(3,4-Dimethoxy-phenyl)-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one 
• 63464-89-1 N-(1-Hydroxy-2-oxo-2-phenyl-ethyl)-3,4-dimethoxy-thiobenzamide 
• 1215309-97-9 C₁₆H₁₅NO₅S 
• 1264748-28-8 C₂₂H₂₀O₃S 
• 1264748-36-8 C₁₉H₂₄O₃S 
• 1264748-29-9 C₁₂H₁₄O₃S 
• 25021-57-2 4-[2-(3,4-dimethoxy-phenyl)-5-methyl-thiazol-4-yl]-aniline 
• 54883-33-9 4-[2-(3,4-dimethoxy-phenyl)-thiazol-4-yl]-aniline 
• 145737-34-4 5-(2-(3,4-dimethoxyphenyl)thiazol-4-yl)indolin-2-one 
• 1253299-12-5 3,5-bis(3,4-dimethoxyphenyl)-1,2,4-thiadiazol 
• 55315-32-7 4-chloromethyl-2-(3,4-dimethoxy-phenyl)-thiazole 

Relevant academic research and scientific papers

Novel Chlorogenic Acid Derivatives and Composition for Treating Inflammatory Disease Comprising the Same

The present invention relates to a novel chlorogenic acid derivative compound having anti-inflammatory activities and to an anti-inflammatory composition including the same as an active ingredient. The chlorogenic acid derivative compound of the present invention controls the overproduction of nitrogen oxide (NO) derived by the treatment of LPS in histiocytes. The chlorogenic acid derivative compound of the present invention inhibits the activation of NF-κB which is an important signal transmittal intermediated transcription factor in oxidant stress and inflammation promoting routes. The chlorogenic acid derivative compound of the present invention has a high possibility of being developed into an agent for treating various inflammatory diseases by inhibiting the overproduction of NO and the activation of NF-κB.

One-step conversion of alcohols into thioesters

A one-step conversion of alcohols into thioesters under solvent-free conditions is reported. The alcohols were reacted with primary thioamides in the presence of p-toluenesulfonic acid under solvent-free conditions to produce the corresponding thioesters in good to excellent yields. Georg Thieme Verlag Stuttgart - New York.

A practical synthesis of 3,4-diethoxybenzthioamide based on Friedel-Crafts reaction with potassium thiocyanate in methanesulfonic acid.

The synthesis of 3,4-diethoxybenzthioamide, the key intermediate for OPC-6535, is achieved by employing Friedel-Crafts reaction of 1,2-diethoxybenzene with potassium thiocyanate in methanesulfonic acid at ambient temperature.

Superoxide radical inhibitor

A superoxide radical inhibitor containing, as an effective ingredient, an azole derivative represented by the general formula (1), STR1 [wherein R1 represents a phenyl group which may have 1-3 lower alkoxy groups as substituent(s) on the phenyl ring, a phenyl group having a lower alkylenedioxy group, or the like; R2 represents a hydrogen atom, a phenyl group, a halogen atom, a lower alkoxycarbonyl group, a lower alkyl group, an amino-lower alkyl group which may have a lower alkyl group as a substituent, a dihydrocarbostyril group, or the like; R3 represents a group of the formula, STR2 (R4B represents a hydroxyl group, a carboxy group, a lower alkenyl group or a lower alkyl group. m represents 0, 1 or 2); X represents a sulfur atom or an oxygen atom] or a salt thereof.

Novel thiazole derivatives as inhibitors of superoxide production by human neutrophils: Synthesis and structure-activity relationships

Neutrophils have an important role in the self-defense systems of organisms through the production of superoxide. On the other hand, it has been proposed that abnormal amounts of superoxide produced by neutrophils are a serious factor in tissue injury. A series of novel thiazole derivatives was prepared and evaluated inhibitory effect on superoxide production by human neutrophils in vitro. Among these compounds, 6-[2-(3,4- diethoxyphenyl)thiazol-4-yl]-pyridine-2-carboxylic acid (OPC-6535) was selected as one of the most promising compounds. The synthesis and structure- activity relationships of these compounds are reported herein.

Synthesis and Antitubercular Activity of 4-(5-Nitro-2-furyl/2-pyrazinyl/1-adamantyl)-2-(alkyl/aryl/arylamino)thiazoles

The reaction of haloketones, obtained from Arndt-Eistert reaction on the acid chlorides of 1-adamantane, 5-nitrofuroic acid and pyrazine-2-carboxylic acid, with different thioamides and thioureas affords the title thiazoles (I-III).Some of them exhibit interesting antitubercular activity at 6.25 to 0.38 μg/ml concentration against H37Rv strain of M. tubercolosis in vitro testing.The structure activity relationship (SAR) has also been discussed.

ELECTRON DEFICIENT HETEROAROMATIC AMMONIOAMIDATES, XVIII. THE SYNTHESIS AND PHOTOCHEMISTRY OF SOME N-ISOQUINOLINO(THIOAMIDATES)

Thioacylation of isoquinolinioamide furnished the N-isoquinolinio(thioamidates) 2a-2c.Depending on the solvent, 2c exists either as a mixture with its tricyclic tautomer 5, or exclusively as the latter.The NMR and mass spectra, and the photochemistry of compounds 2a-2c are discussed.The photoproducts obtained include 3,4-dimethoxybenzonitrile, 3,4-dimethoxy(thiobenzamide), O-ethyl thiocarbamate, 1(2H)-isoquinolinethione (7a), 1(2H)-isoquinolinone (7b) and thiadiazoloisoquinolin-4-ium-2-olate (8a).Differences between the fragmentation upon electron impact and the photochemistry of the thioamidates of Types 1 and 2, as well as between the photochemistry of the thioamidates 2 and their amidate counterparts of Type 3 are discussed.Potassium permanganate oxidation of thiadiazoloisoquinolin-4-ium-2-thiolate (8b) furnishes the olate 8a and 1-isoquinolyl thiocyanate (12).