58953-14-3

Upstream product

• 79-30-1 isobutyryl chloride 
• 74-86-2 acetylene 
• 87025-28-3 1,1-dichloro-4-methylpentan-3-one 
• 563-80-4 3-methyl-butan-2-one 
• 42731-26-0 (Z)-1-Hydroxy-4-methyl-pent-1-en-3-one 
• 13531-82-3 4-methylpent-1-yn-3-one 

Downstream Products

• 98483-00-2 2-hydroxy-6-isopropyl-nicotinic acid 
• 5782-69-4 2-hydroxy-6-isopropyl-nicotinonitrile 
• 62969-85-1 6-isopropyl-pyridin-2-ol 
• 160596-45-2 (E)-2-(3-hydroxy-3-phenyl-1-butenyl)-2-isopropyl-1,3-dioxolane 

Relevant academic research and scientific papers

Therapeutic agents

Compounds of formula (I) which includes pharmaceutically acceptable salts thereof and stereoisomers thereof: STR1 wherein: R 1 represents H or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino): C 1-6 alkyl, C 1-6 alkoxy or C 1-6 alkanoyl; R 2 and R 3 independently represent H or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino): C 1-6 alkyl, C 1-6 alkoxy or C 1-6 alkanoyl, C 1-6 alkylthio, C 1-6 alkylsulphinyl or C 1-6 alkylsulphonyl; R 4 and R 5 combined together with the carbon atom to which they are attached represent C 3-6 cycloalkylidene (each alkyl or cycloalkylidene being optionally substituted with one or more of halo, cyano, hydroxy, amino or C 1-6 alkyl); and R 6, R 7 and R 8 independently represent H, halo, hydroxy, mercapto, cyano or one of the following groups (optionally substituted with one or more of halo, cyano, hydroxy or amino; and any nitrogen atom being optionally substituted with one or more C 1-6 alkyl): C 1-6 alkyl, C 1-6 alkoxy or C 1-6 alkanoyl, C 1-6 alkylthio, C 1-6 alkylsulphinyl, etc; have utility in the treatment and/or prophylaxis or seizures, neurological disorders such as epilepsy and/or conditions in which there is neurological damage such as stroke, brain trauma, head injuries and haemorrhage.

(Z)- AND (E)-γ-OXIDO FUNCTIONALIZED sp2-HYBRIDIZED ORGANOLITHIUM COMPOUNDS. PREPARATION AND SYNTHETIC APPLICATIONS.

The reaction of methyl (Z)-3-chloroacrylate (6) with a Grignard reagent and further lithiation with lithium powder led to the (Z)-intermediates (7), which by reaction with deuterium oxide or dimethyl disulfide led to the corresponding deuterio or methylthio derivatives (8)-(12) with a Z configuration; the treatment of the intermediate (7) with N,N-dimethylformamide yielded the cyclic hemiacetal (13), and in the reaction with carbon dioxide or ethyl chloroformate the corresponding α,β-butenolides (14)-(18) were isolated.Starting from (E)-2-chlorovinyl isopropyl ketone (19) the corresponding (E)-intermediate (20) was prepared by the same procedure; the in situ reaction of this dianion with different electrophiles (deuterium oxide, carbon dioxide, N,N-dimethylformamide, and isobutyraldehyde) led to the expected bifunctionalized compounds (21)-(25) with an E configuration.

STEREOSELECTIVE SYNTHESIS AND THERMAL BEHAVIOR OF (Z)-EPOXYHEXENYNES: A SIMPLE AND GENERAL ROUTE TO 2-VINYLFURANS

An efficient approach for the synthesis of 2,3-disubstituted furans (2a-j/3a-j) is described by using the thermally induced rearrangement of epoxyhexenynes (1a-j) which are prepared by streoselective synthesis of the (Z)-pentenynals 10 and subsequent Darz