5896-29-7Relevant articles and documents
With Wnt signal path to inhibit the active heterocyclic compounds (by machine translation)
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Paragraph 0061-0063; 0068-0069, (2017/08/15)
The invention relates to a signal path with Wnt inhibiting activity of a heterocyclic compound, including the compound and its pharmaceutically acceptable salt, various isotope, various isomers or various crystal structure, having the general formula I of the structure shown in: the invention relates to a compound and its joint application composition can effectively inhibit the Wnt signal path, can be used for the treatment or prevention of a disorder associated with a Wnt signal path. (by machine translation)
TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS
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Page/Page column 74, (2010/09/17)
The present teachings relate to compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, R4, X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I and methods of inhibiting matrix metalloproteinases, in particular, MMP-12, that may be involved in pathological disorders found in mammals, including a human.
The Decomposition of Arenediazonium Tetrafluoroborates with Halo- and Azidotrimethylsilanes in Nonaqueous Solvents
Keumi, Takashi,Umeda, Toshiaki,Inoue, Yoshinori,Kitajima, Hidehiko
, p. 89 - 95 (2007/10/02)
The reaction of arenediazonium tetrafluoroborates with chlorotrimethylsilane in a tetrahydrofuran/N,N-dimethylformamide (DMF) (5v/3v) solution afforded the protodediazotization products in high yields.The reactions of the diazonium salts with halotrimethylsilanes in DMF were found to give the corresponding haloarenes.Among the halodediazotization reactions, the iododediazotization with iodotrimethylsilane proceeded smoothly at room temperature to give the iodoarenes in excellent yields.In a similar manner, a variety of azidoarenes were obtained in cosistently high yields by the treatment of arenediazonium tetrafluoroborates with azidotrimethylsilane in a DMF solution.