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Ethyl [(4-oxo-3-phenyl-4H-chromen-7-yl)oxy]acetate is a complex organic compound with the chemical formula C18H14O5. It is a derivative of the 4H-chromen-4-one class of compounds, which are characterized by a benzopyran core with a carbonyl group at the 4-position. This specific compound features a 3-phenyl substitution, which adds a phenyl ring to the 3-position of the chromen-4-one structure, and a 7-hydroxy group that is ether-linked to an acetate ester. The compound is known for its potential applications in the pharmaceutical and chemical industries, particularly as an intermediate in the synthesis of various biologically active compounds. Its structure and properties make it a valuable building block for the development of new drugs and other chemical products.

5897-05-2

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5897-05-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5897-05-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,8,9 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 5897-05:
(6*5)+(5*8)+(4*9)+(3*7)+(2*0)+(1*5)=132
132 % 10 = 2
So 5897-05-2 is a valid CAS Registry Number.

5897-05-2Relevant academic research and scientific papers

Synthesis and biological evaluation of Complex I inhibitor R419 and its derivatives as anticancer agents in HepG2 cells

Huang, Yaping,Sun, Geng,Wang, Pengfei,Shi, Rui,Zhang, Yanchun,Wen, Xiaoan,Sun, Hongbin,Chen, Caiping

, p. 2957 - 2960 (2018/07/21)

In this study, Complex I inhibitor R419 was firstly revealed to have significant anticancer activity against HepG2 cells (IC50 = 5.2 ± 0.9 μM). Based on this finding, a series of R419 derivatives were synthesized and biologically evaluated. As results, 9 derivatives were found to have obvious anticancer activity. Among them, H20 exhibited the most potent activity (IC50 = 2.8 ± 0.4 μM). Mechanism study revealed that H20 caused severe depletion of cellular ATP, dose-dependently activated AMPK, decreased Bcl-2/Bax ratio and induced necrotic cell death. Most importantly, H20 displayed definite inhibitory activity against Complex I.

Ground mixture

-

, (2008/06/13)

A ground mixture of a poorly soluble crystalline drug and an adsorbent is remarkably improved in the rates of dissolution and adsorption of the drug.

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