58972-42-2

Upstream product

• 108-86-1 bromobenzene 
• 118-93-4 o-hydroxyacetophenone 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 39477-86-6 1-phenyl-1-(2-hydroxyphenyl)ethene 
• 1396690-38-2 2-(1-phenylvinyl)phenyl formate 
• 4355-42-4 3-methyl-3-phenylbenzofuran-2(3H)-one 
• 61198-52-5 3,4-dihydro-4-phenyl-2H-1-benzopyran-2-one 
• 13054-95-0 2,3-diphenylbenzofuran 
• 29909-72-6 3-Phenylbenzofuran 
• 1644258-02-5 benzyl (E)-3-[2-butyl-4-(2-methoxyphenyl)-10-oxospiro[4.5]deca-1,3,6,8-tetraen-1-yl]prop-2-enoate 
• 1644258-01-4 benzyl (2E)-3-{2-Butyl-10-oxo-4-phenylspiro[4.5]deca-1,3,6,8-tetraen-1-yl}prop-2-enoate 
• 1644258-00-3 1-ethenyl-4-phenyl-2-(2-phenylethyl)spiro[4.5]deca-1,3,7,9-tetraen-6-one 
• 1644257-95-3 2-{2-[(tert-butyldimethylsilyl)oxy]ethyl}-1-[(E)-2-(4-methylphenyl)ethenyl]-4-phenylspiro[4.5]deca-1,3,7,9-tetraen-6-one 
• 1644257-91-9 1,4-diphenyl-2-propylspiro[4.5]deca-1,3,7,9-tetraen-6-one 
• 1644257-90-8 2-methyl-1,4-diphenylspiro[4.5]deca-1,3,7,9-tetraen-6-one 
• 1610359-50-6 1,2,4-triphenylspiro[4,5]deca-1,3,7,9-tetraen-6-one 

Relevant academic research and scientific papers

Asymmetric Hydroesterification of Diarylmethyl Carbinols

An efficient asymmetric hydroesterfication of diarylmethyl carbinols is developed for the first time with a Pd-WingPhos catalyst, resulting in a series of chiral 4-aryl-3,4-dihydrocoumarins in excellent enantioselectivities and good yields. The method features mild reaction conditions, a broad substrate scope, use of easily accessible starting materials, and low palladium loadings. A plausible stereochemical model is also proposed with the Pd-WingPhos catalyst. This method has enabled a 4-step asymmetric synthesis of (R)-tolterodine from readily available starting materials.

A chiral phosphorus alkene ligand, synthetic method and the application of the asymmetric reaction in (by machine translation)

The invention relates to a chiral phosphorus alkene ligand, a synthesis method and application thereof in asymmetric reaction. Specifically, the invention discloses a chiral phosphorus alkene compound, which has a structural formula shown as formula I or formula II in the specification, wherein R, R, R, R, R, R, R, R and R are defined in the specification. The chiral phosphorus alkene compound can be prepared from chiral 2, 2'-binaphthol or its derivative as the starting material through two to four steps of reaction by means of four methods. The chiral phosphorus alkene compound can be used as a chiral ligand in asymmetric addition reaction of rhodium catalyzed boric acid and prochiral C=X (X=C, O, N) double bond, and can achieve good yield and enantioselectivity.

One-Step Synthesis of Substituted Benzofurans from ortho- Alkenylphenols via Palladium-Catalyzed C=H Functionalization

A dehydrogenative oxygenation of C(sp2)=H bonds with intramolecular phenolic hydroxy groups has been developed, which provides a straightforward and concise access to structurally diversely benzofurans from ortho-alkenylphenols. The reaction is catalyzed by palladium on carbon (Pd/C) without any oxidants and sacrificing hydrogen acceptors.

Synthesis of spirocyclic enones by rhodium-catalyzed dearomatizing oxidative annulation of 2-alkenylphenols with alkynes and enynes

The dearomatizing oxidative annulation of 2-alkenylphenols with alkynes and enynes proceeds with high yields and regioselectivities under RhIII catalysis. These reactions are successful using Cu(OAc)2 or air as the stoichiometric oxi

Palladium(II)-catalyzed direct carboxylation of alkenyl C-H bonds with CO2

Pd-catalyzed direct carboxylation of alkenyl C-H bonds with carbon dioxide was realized for the first time. Treatment of 2-hydroxystyrenes and a catalytic amount of Pd(OAc)2 with Cs2CO3 under atmospheric pressure of CO2 afforded corresponding coumarins in good yield. Furthermore, isolation of the key alkenylpalladium intermediate via C-H bond cleavage was achieved. The reaction was proposed to undergo reversible nucleophilic addition of the alkenylpalladium intermediate to CO2.

Remarkable improvement achieved by imidazole derivatives in ruthenium-catalyzed hydroesterification of alkenes using formates

Imidazole derivatives are revealed to be effective ligands in the Ru-catalyzed hydroesterification of alkenes using formates, affording one-carbonelongated esters in high yields. Further, intramolecular hydroesterification was successfully performed to give lactones for the first time. Imidazole derivatives can contribute to promote the reaction as well as to suppress the undesired decarbonylation of formate. Toxic CO gas, a directing group, and large excess alkenes are not required.

Facile construction of functionalized 4H-chromene via tandem benzylation and cyclization

A series of functionalized 4H-chromenes have been constructed by using a novel FeCl3-catalyzed benzylation-cyclization tandem reaction. The Royal Society of Chemistry.

Design, synthesis, and evaluation of potential inhibitors of brassinin glucosyltransferase, a phytoalexin detoxifying enzyme from Sclerotinia sclerotiorum

Sclerotinia sclerotiorum is a fungal pathogen, which causes stem rot in crucifer crops and in several other plant families resulting in enormous yield losses all over the world. Brassinin is a phytoalexin produced by crucifer plants as part of a general d

Photochemistry of 3-substituted bicyclo[3.1.0]hex-3-en-2-ones. Regioselective synthesis of ortho-substituted phenols by Pauson-Khand reaction

(equation presented) 3-Substituted bicyclo[3.1.0]hex-3-en-2-ones 3, easily obtained by Pauson-Khand reaction between terminal alkynes and cyclopropene, have been quantitatively converted into ortho-substituted phenols 4 by irradiation with UV light (350 n

Intramolecular (2 + 2) Cycloadditions of Phenoxyketenes

The intramolecular (2 + 2) cycloaddition of phenoxyketenes to alkenyl groups provides an efficient route to polycyclic cyclobutanones. (o-Vinylphenoxy)- and (o-allylphenoxy)ketenes were prepared from the corresponding acid chlorides by treatment with trie