15185-05-4

Basic information

• Product Name: 2H-1-Benzopyran-2-one, 4-phenyl-
• Synonyms: 2H-1-Benzopyran-2-one, 4-phenyl-;4-Phenyl-2H-1-benzopyran-2-one
• CAS NO: 15185-05-4
• Molecular Formula: C₁₅H₁₀O₂
• Molecular Weight: 222.24
• Mol File: 15185-05-4.mol
• Article Data: 91

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-1-Benzopyran-2-one, 4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-one, 4-phenyl-(15185-05-4)
• EPA Substance Registry System: 2H-1-Benzopyran-2-one, 4-phenyl-(15185-05-4)

Safety Data

• Hazardous Substances Data: 15185-05-4(Hazardous Substances Data)

Upstream product

• 17831-88-8 4-chloro-2H-1-benzopyran-2-one 
• 98-80-6 phenylboronic acid 
• 100379-82-6 4-diethylphosphonyloxycoumarin 
• 38111-44-3 phenylzinc(II) bromide 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 1002130-71-3 methyl 3-[2-(methoxymethoxy)phenyl]propiolate 
• 425686-45-9 methyl 3-(2-hydroxyphenyl)propiolate 
• 533-58-4 2-Iodophenol 
• 103-26-4 Methyl cinnamate 
• 117-99-7 2-Hydroxybenzophenone 
• 108-24-7 acetic anhydride 
• 113777-29-0 4-(trifluoromethylsulfonyloxy)coumarin 
• 75-36-5 acetyl chloride 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Downstream Products

• 29909-72-6 3-Phenylbenzofuran 
• 1379805-13-6 3-(2-hydroxyphenyl)-3-phenylacrylic acid 

Relevant articles and documents

Rh(I)-catalyzed cross-coupling reactions of alkenyl tosylates with potassium aryltrifluoroborates

RhCl(PPh3)3/DPPF was successfully employed as an efficient catalyst in the Suzuki-Miyaura cross-coupling reactions of potassium aryltrifluoroborates with alkenyl tosylates, affording the corresponding products in good to excellent yi

Magnesium bis(trifluoromethane)sulfonimide: An efficient catalyst for the synthesis of coumarins under solvent-free conditions

Magnesium bis(trifluoromethane)sulfonimide [Mg(NTf2) 2] is an efficient catalyst for the synthesis of coumarins via the Pechmann condensation reaction of phenols and β-ketoesters under solvent-free conditions.

An evaluation of palladium-based catalysts for the base-free borylation of alkenyl carboxylates

Synthesis of organoboron derivatives is a key application of catalytic cross-coupling, with the Pd-catalyzed Miyaura borylation among the most versatile methods available. We have evaluated several Pd-based systems for borylation of alkenyl acetates and p

Coumarins by Direct Annulation: β-Borylacrylates as Ambiphilic C3-Synthons

Modular β-borylacrylates have been validated as programmable, ambiphilic C3-synthons in the cascade annulation of 2-halo-phenol derivatives to generate structurally and electronically diverse coumarins. Key to this [3+3] disconnection is the BPin unit which serves a dual purpose as both a traceless linker for C(sp2)–C(sp2) coupling, and as a chromophore extension to enable inversion of the alkene geometry via selective energy transfer catalysis. Mild isomerisation is a pre-condition to access 3-substituted coumarins and provides a handle for divergence. The method is showcased in the synthesis of representative natural products that contain this venerable chemotype. Facile entry into π-expanded estrone derivatives modified at the A-ring is disclosed to demonstrate the potential of the method in bioassay development or in drug repurposing.