5899-19-4

Usage

Uses

Used in Pharmaceutical Industry:
2-[(2-iodobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylic acid is used as a potential pharmaceutical agent for its unique structural features and functional groups that may allow for targeted biological interactions. The presence of the iodine atom, benzoyl and amino groups, as well as the carboxylic acid functionality, could contribute to its potential therapeutic effects and applications in drug development.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-[(2-iodobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylic acid serves as a valuable compound for research and development. Its complex structure and functional groups make it an interesting subject for studying its interactions with biological targets, which could lead to the discovery of new therapeutic agents or the optimization of existing ones.

Upstream product

• 24195-35-5 2-<2-Hydroxy-benzyl>-1-semicarbazono-cyclohexan 
• 92300-32-8 1-(cyclohexylmethyl)-2-methoxybenzene 
• 110-82-7 cyclohexane 
• 1745-81-9 o-Allylphenol 
• 3137-39-1 bis(2-oxocyclohexyl)methane 
• 135-02-4 ortho-anisaldehyde 
• 931-50-0 cyclohexylmagnesium bromide 
• 578-57-4 2-bromoanisole 
• 2043-61-0 cyclohexanecarbaldehyde 
• 108-95-2 phenol 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 3954-12-9 phenyl cyclohexanecarboxylate 
• 18066-52-9 cyclohexyl(2-hydroxyphenyl)methanone 

Downstream Products

• 54954-57-3 1-bromo-4-(cyclohexylmethoxy)benzene 
• 1542756-10-4 ethyl 2-(1,1'-biphenyl-3-cyclohexylmethyl-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate 
• 1542756-13-7 ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate 
• 1542756-15-9 ethyl 2-(1,1'-biphenyl-3,3'-(cyclohexylmethyl)-4'-[2-(dimethylamino)ethoxy]-4-oxy) acetate 
• 1243432-33-8 4-Bromo-2-(cyclohexylmethyl)phenol 
• 1542755-50-9 2-(cyclohexylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 
• 1542755-61-2 ethyl 2-(4-bromo-2-(cyclohexylmethyl)phenoxy)acetate 
• 1542755-81-6 ethyl 2-(1,1'-biphenyl-3-cyclohexylmethyl-4'-ol-4-oxy) acetate 
• 1542755-83-8 ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-ol-4-oxy) acetate 
• 1542755-85-0 ethyl 2-(1,1'-biphenyl-3,3'-di(cyclohexylmethyl)-4'-ol-4-oxy) acetate 

Relevant academic research and scientific papers

4,4′-Unsymmetrically substituted 3,3′-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors

A series of unsymmetrically substituted biphenyl compounds was designed as alpha helical proteomimetics with the aim of inhibiting the binding of coactivator proteins to the nuclear hormone receptor coactivator binding domain. These compounds were synthes

Xanthene derivatives and ortho-substituted phenols - Products from dehydrogenation of acyclic 1,5-diketones

Xanthene derivatives and ortho-substituted phenols were obtained during the dehydrogenation of 1,5-diketones and their ketol forms at a Pt/C catalyst at 280-320°C. 2005 Springer Science+Business Media, Inc.

Photoreactions of trans-1-o-Hydroxyphenyl-2-phenylcyclopropane

The photochemistry of trans-1-o-hydroxyphenyl-2-phenylcyclopropane, trans-1, was studied under a variety of experimental conditions. Direct irradiation through quartz in cyclohexane gave rise mainly to ring-expanded products, 2-phenyl-3,4-dihydro-2H-benzopyran, 2, 2-benzyl-2,3-dihydrobenzofuran, 3, and 1-o-hydroxyphenylindan, 4. The major products, 2 and 3, are rationalized by intramolecular proton transfer. However, a significant fraction of 3 is formed via ring-opening to cinnamylphenol, 5. An additional product, o-(α-cyclohexylmethyl)phenol, 7, suggests fragmentation of trans-1 and (formal) insertion of o-hydroxyphenylcarbene into cyclohexane. Direct irradiation in methanol produced methanol adducts 8 and 9 instead of 2, 3,4, or 7. Finally, acetone-sensitized irradiation of trans-1 resulted in geometric isomerization to cis-1; this result can be rationalized via a biradical intermediate.

Metal cation-exchanged montmorillonite (Mn+-mont)-catalysed aromatic alkylation with aldehydes and ketones

The alkylation of aromatic compounds with aldehydes and ketones in the presence of a variety of metal cation-exchanged montmorillonites (Mn+-mont; Mn+ = Zr4+, Al3+, Fe3+, Zn2+, H+, Na+) has been investigated. Al3+- and Zr4+-Monts are revealed to be effective as catalysts, while no reaction takes place with Na+-mont. Al3+-Mont-catalysed alkylation of phenol with several aldehydes produces mainly or almost solely the corresponding gem-bis(hydroxyphenyl)alkanes (bisphenols) in good yields, while that with several ketones affords selectively the corresponding alkylphenols in moderate to good yields. The alkylation always occurs at the carbonyl carbon without any skeletal rearrangement and the kind of products depends much on the steric hindrance of an electrophilic intermediary carbocation. The alkylation of anisole, veratrole and p-cresol proceeds well, while that of toluene, benzene, chlorobenzene and nitrobenzene scarcely occurs.

Photochemistry of o-Allylphenol. Identification of the Minor Products and New Mechanistic Proposals

The photochemistry of o-allylphenol (1) in cyclohexane has been reinvetigated.Besides the previously reported cyclic ethers 2 and 3, seven additional minor photoproducts have been detected.Spectroscopic methods, coupled with independent synthesis, have allowed their identification as 2-methylbenzofuran (5), o-propylphenol (8), the epoxide 4, the dihydroxy compound 9, the cyclohexyl ether 6, o-(cyclohexylmethyl)phenol (10), and the dimer 7.Their formation is rationalized through new mechanistic pathways, which involve initial intermolecular electron and/or proton transfer between two molecules of o-allylphenol, as well as di-?-methane rearrangement.Key intermediates appear to be radical V, carbenium ion IX, and carbene XI.This is supported by photolysis of o-allylphenyl acetate (11), which leads to the formation of a radical pair, followed by in cage recombination to the photo-Fries products 12 and 13 or, alternatively, diffusion of the radicals out of the solvent cage to afford the minor products 2, 5, and 6, identical to those obtained by photolysis of 1.