59009-70-0

Upstream product

• 50-00-0 formaldehyd 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 100-46-9 benzylamine 

Downstream Products

• 118958-17-1 N,N'-dibenzyl-9,9-dimethoxy-3,7-diazabicyclo<3.3.1>nonane hydroperchlorate 
• 129340-90-5 3,7-dibenzyl-3,7-diazabicyclo<3.3.1>nonan-9,9-diol hydroperchlorate 
• 20397-57-3 5,7-Diazaadamantan-2-one 
• 909037-16-7 3,7-dibenzyl-9,9-(1,3-dithiolan-2-yl)-3,7-diazabicyclo[3.3.1]nonane 
• 228270-23-3 3,7-Dibenzyl-9-hydroxy-9-methyl-3,7-diazabicyclo[3.3.1]nonane 
• 280-74-0 3,7-diazabicyclo{3.3.1}nonane 
• 14789-33-4 3,7-dimethyl-7-aza-3-azoniabicyclo[3.3.1]nonane 
• 58324-90-6 3,7-dibutyl-7-aza-3-azoniabicyclo[3.3.1]nonane 
• 909037-18-9 3,7-dipropyl-7-aza-3-azoniabicyclo[3.3.1]nonane 
• 59009-71-1 N,N'-dibenzyl-3,7-diazabicyclo[3.3.1]nonane 

Relevant academic research and scientific papers

Synthesis of chiral amino alcohols embodying the bispidine framework and their application as ligands in enantioselectively catalyzed additions to C=O and C=C groups

Two generally applicable routes for the synthesis of chiral amino alcohols embodying the bispidine framework have been developed. In linear route A the bispidine framework is built up successively from chiral primary amines via intermediate formation of a piperidinone and a bispidinone. In convergent route B an achiral bispidine is formed first and then the N- substituents are introduced by reaction of the nitrogen bases with chiral electrophiles. In order to determine if the bispidine core and its N- substituents can influence the steric course of enantioselective transformations, bispidine amino alcohols built up by these two routes were investigated as chiral ligands in the enantioselectively catalyzed addition of diethylzinc to aldehydes and chalcone. In general, tridentate ligands containing one chiral amino alcohol fragment and a second amino substituent without a stereogenic center were more efficient than tetradentate ligands with two amino alcohol structural units. With the best ligands the enantioselective addition of diethylzinc to aromatic and aliphatic aldehydes proceeded with 83-98% ee and the nickel-catalyzed addition of diethylzinc to chalcone was achieved with up to 85% ee.

3,7,9-Triheterabicyclodecan-10-ones: An Unusual Family of Heterocycles Obtained from 3,7-Diheterabicyclononan-9-ones

A series of new 3,7,9-triheterabicyclodecan-10-ones is reported for the first time.Members of the family of 3,7-diheterabicyclononan-9-ones served as precursors of the title compounds.Spectral evidence suggests the 3,7,9-triheterabicyclodecan-10-ones exist in a chair-boat (CB) ->/nonan-9-one precursors in solution may influence the ease of oxygen and nitrogen insertion in the ring enlargement to give the title molecules.Confirmation that three members of the bicyclodecan-10-ones exist in BC forms in the solid state was achieved via single crystal X-ray diffraction analysis for 7-benzyl-3-thia-7,9-diazabicyclodecan-10-one (4a), 3,7-dibenzyl-3,7,9-triazabicyclodecan-10-one (4c), and 3,7-dibenzyl-9-oxa-3,7-diazabicyclodecan-10-one (4d).

A study of the synthesis and antiarrhythmic properties of selected 3,7-diheterabicyclo[3.3.1]nonanes with substituents at the 2,4-positions and at the 9-position

Some members of the family of 3,7-diheterabicyclo[3.3.1]nonanes with substituents at the 2-, 4- and 9-positions were synthesized via a Mannich reaction. Hearts of anesthetized dogs with myocardial infarctions were subjected to ventricular tachycardia (VT)

Certain 3-selena-7-aza-bicyclo[3.3.1]nonanes as antiarrhythmic agents

3-7-Diheterabicylo[3.3.1]nonanes and derivatives thereof are disclosed. Their method of preparation and use as antiarrhythmic agents is given.