20397-57-3

Basic information

• Product Name: 1,3-diazatricyclo[3.3.1.1~3,7~]decan-4-one
• CAS NO: 20397-57-3
• Molecular Formula: C₈H₁₂N₂O
• Molecular Weight: 152.1937
• Mol File: 20397-57-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 287.6°C at 760 mmHg
• Flash Point: 134.4°C
• Density: 1.3g/cm³
• Vapor Pressure: 0.00246mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 1,3-diazatricyclo[3.3.1.1~3,7~]decan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-diazatricyclo[3.3.1.1~3,7~]decan-4-one(20397-57-3)
• EPA Substance Registry System: 1,3-diazatricyclo[3.3.1.1~3,7~]decan-4-one(20397-57-3)

Safety Data

• Hazardous Substances Data: 20397-57-3(Hazardous Substances Data)

Upstream product

• 53120-58-4 5,7-Diazaadamantan-2-ol 
• 100-97-0 hexamethylenetetramine 
• 96-22-0 pentan-3-one 
• 78693-62-6 1,3-Bis(phenylthio)-5,7-diazaadamantan-2-one 
• 50-00-0 formaldehyd 
• 59009-70-0 3,7-bis(phenylmethyl)-3,7-diazabicyclo[3.3.1]nonan-9-one 

Downstream Products

• 80808-96-4 1,5-dimethyl-9-oxo-3,7-diazabicyclo-<3.3.1>nonane 
• 107606-92-8 3,7-dibenzyl-1,5-dimethyl-9-oxo-3,7-diazabicyclo<3.3.1>nonane 
• 80808-90-8 (1,5-dimethyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3,7-diyl)bis(phenylmethanone) 

Relevant articles and documents

Improved synthesis of 1,3-diaza-6-adamantanone

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Design and Evaluation of Bispidine-Based SARS-CoV-2 Main Protease Inhibitors

For the first time, derivatives of 3,7-diazabicyclo[3.3.1]nonane (bispidine) were proposed as potential inhibitors of the SARS-CoV-2 main viral protease (3-chymotrypsin-like, 3CLpro). Based on the created pharmacophore model of the active site of the protease, a group of compounds were modeled and tested for activity against 3CLpro. The 3CLpro activity was measured using the fluorogenic substrate Dabcyl-VNSTLQSGLRK(FAM)MA; the efficiency of the proposed approach was confirmed by comparison with literature data for ebselen and disulfiram. The results of the experiments performed with bispidine compounds showed that 14 compounds exhibited activity in the concentration range 1-10 μM, and 3 samples exhibited submicromolar activity. The structure-activity relationship studies showed that the molecules containing a carbonyl group in the ninth position of the bicycle exhibited the maximum activity. Based on the experimental and theoretical results obtained, further directions for the development of this topic were proposed.