59010-47-8

Upstream product

• 67-56-1 methanol 
• 127275-12-1 4-Chloro-3-methylphenyl Hydrogen Succinate 

Downstream Products

• 59010-46-7 4-(2-Hydroxy-4-methylphenyl)-4-oxobutanoic Acid 
• 59010-48-9 methyl 3-[2-(2,3-epoxypropoxy)-4-methylbenzoyl]propionate 

Relevant academic research and scientific papers

Photochemical Versus Aluminium Chloride-Catalyzed Fries Rearrangement of Aryl Hydrogen Succinates. Synthesis of 2(3H)-Furanones

The photochemical and aluminium chloride-catalyzed Fries rearrangement of a series of aryl hydrogen succinates 3 a-f to the corresponding 4-oxoacids 1 a-f are compared.Both approaches are complementary: the photochemical process is more general and becomes the method of choice for the succinoylation of phenols supporting alkoxy or hydroxy substituents, while the classical rearrangement is superior in the presence of alkyl or halogen substituents.These results are applied to the preparation of the 2(3H)-furanones 2 a-f. - Keywords: Fries rearrangement; Photo-Fries rearrangement; Aryl hydrogen succinates; 4-Oxoacids; 2(3H)-Furanones.

PYRIDAZINETHIONES

Substituted phenyl pyridazinethiones which are useful intermediates in the preparation of substituted phenylhydrazinopyridazines which have . beta.-adrenergic blocking and vasodilator activity.

3-Substituted-phenyl-6-hydrazine pyridazines

The compounds are 3-((3-substituted amino-2-hydroxypropoxy)-phenyl)-6-hydrazino pyridazines which have β-adrenergic blocking and vasodilator activity.