590371-81-6 Usage
General Description
2-CHLORO-4-(TRIFLUOROMETHYL)NICOTINIC ACID, also known as CTFNA, is a chemical compound with the molecular formula C7H4ClF3NO2. It is a chlorinated derivative of nicotinic acid and contains a trifluoromethyl group, which makes it highly reactive and useful in various chemical reactions. CTFNA is often used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also employed in the production of herbicides and insecticides due to its potent biological activities. Additionally, CTFNA has potential applications in the field of medicinal chemistry, where it is being investigated as a possible drug candidate for the treatment of various diseases and conditions. Overall, CTFNA is a versatile and important chemical that is widely used in research and industry.
Check Digit Verification of cas no
The CAS Registry Mumber 590371-81-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,9,0,3,7 and 1 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 590371-81:
(8*5)+(7*9)+(6*0)+(5*3)+(4*7)+(3*1)+(2*8)+(1*1)=166
166 % 10 = 6
So 590371-81-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H3ClF3NO2/c8-5-4(6(13)14)3(1-2-12-5)7(9,10)11/h1-2H,(H,13,14)
590371-81-6Relevant articles and documents
Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids
Cottet, Fabrice,Schlosser, Manfred
, p. 11869 - 11874 (2007/10/03)
Although there are many conceivable ways to funtionalize, and specifically carboxylate, 2-chloro-4-(trifluoromethyl)pyridine optionally at all three vacant positions, it is more straightforward to prepare only the 2-chloro-4- (trifluoromethyl)pyridine-3-carboxylic acid (1) from this precursor and the other 6-chloro-4-(trifluoromethyl)pyridine-2- and -3-carboxylic acids (2 and 3) from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl)pyridine. In the same manner, it proved more convenient to convert 5-chloro-2-(trifluoromethyl) pyridine in only two of the corresponding acids (6 and 7) and to make the third one (8) from 3-bromo-5-chloro-2-(trifluoromethyl)pyridine as an alternative starting material. All model substrates for functionalization were readily accessible from the correspondingly substituted chloroiodopyridine through heavy halogen displacement by in situ generated (trifluoromethyl)copper. Graphical Abstract
