590372-08-0

Basic information

• Product Name: 2-BROMO-8-IODO-4-(TRIFLUOROMETHYL)QUINOLINE
• Synonyms: 2-BROMO-8-IODO-4-(TRIFLUOROMETHYL)QUINOLINE;Quinoline, 2-broMo-8-iodo-4-(trifluoroMethyl)-
• CAS NO: 590372-08-0
• Molecular Formula: C10H4BrF3IN
• Molecular Weight: 401.9491396
• Mol File: 590372-08-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-BROMO-8-IODO-4-(TRIFLUOROMETHYL)QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-8-IODO-4-(TRIFLUOROMETHYL)QUINOLINE(590372-08-0)
• EPA Substance Registry System: 2-BROMO-8-IODO-4-(TRIFLUOROMETHYL)QUINOLINE(590372-08-0)

Safety Data

• Hazardous Substances Data: 590372-08-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-BROMO-8-IODO-4-(TRIFLUOROMETHYL)QUINOLINE is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-BROMO-8-IODO-4-(TRIFLUOROMETHYL)QUINOLINE serves as a building block for the synthesis of diverse organic compounds. Its specific reactions and properties contribute to the creation of novel molecules with potential applications in drug discovery and development.
Used in Material Science:
2-BROMO-8-IODO-4-(TRIFLUOROMETHYL)QUINOLINE is also utilized in the development of new materials, taking advantage of its unique chemical properties to create innovative compounds with potential applications in various industries.
Safety Considerations:
It is important to handle 2-BROMO-8-IODO-4-(TRIFLUOROMETHYL)QUINOLINE with caution, as it may pose hazards if not properly managed. Adequate safety measures should be taken during its synthesis, storage, and use to ensure the safety of researchers and the environment.

Upstream product

• 590372-06-8 8-iodo-4-(trifluoromethyl)quinolin-2(1H)-one 
• 615-43-0 2-iodophenylamine 
• 663192-22-1 N-(2-iodophenyl)-4,4,4-trifluoro-4-oxobutanamide 

Downstream Products

• 590372-23-9 2-bromo-4-trifluoromethyl-8-quinolinecarboxylic acid 
• 590371-53-2 4-trifluoromethyl-8-quinolinecarboxylic acid 

Relevant articles and documents

An Improved Access to 4-Trifluoromethyl-2(1H)-quinolinones: The "Watering Protocol"

Condensation of anilines with ethyl 4,4,4-trifluoroacetoacetate (7) to afford the corresponding 4,4,4-trifluoro-3-oxobutaneanilides (10), precursors to 4-(trifluoromethyl)-2-quinolinones (11), can be favored and the competing condensation to produce the e

Recommendable routes to trifluoromethyl-substituted pyridine- and quinolinecarboxylic acids

As part of a case study, rational strategies for the preparation of all ten 2-, 3-, or 4-pyridinecarboxylic acids and all nine 2-, 3-, 4-, or 8-quinolinecarboxylic acids bearing trifluoromethyl substituents at the 2-, 3-, or 4-position were elaborated. The trifluoromethyl group, if not already present in the precursor, was introduced either by the deoxygenative fluorination of suitable carboxylic acids with sulfur tetrafluoride or by the displacement of ring-bound bromine or iodine by trifluoromethylcopper generated in situ. The carboxy function was produced by treatment of organolithium or organomagnesium intermediates, products of halogen/metal or hydrogen/ metal permutation, with carbon dioxide. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).