590372-23-9 Usage
Uses
Used in Pharmaceutical Industry:
2-Bromo-4-trifluoromethyl-8-quinolinecarboxylic Acid is used as an intermediate in the synthesis of various fluoroquinolone antibiotics. These antibiotics are effective in treating a wide range of bacterial infections due to their broad-spectrum activity and ability to target essential bacterial processes, such as DNA replication and protein synthesis.
Used in Drug Development and Medicinal Chemistry:
2-Bromo-4-trifluoromethyl-8-quinolinecarboxylic Acid holds potential for the development of new therapeutic agents for bacterial infections. Its unique structure and antimicrobial properties make it a promising candidate for the design and synthesis of novel antibiotics to combat drug-resistant bacteria and address the growing need for new antimicrobial agents in the medical field.
Check Digit Verification of cas no
The CAS Registry Mumber 590372-23-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,9,0,3,7 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 590372-23:
(8*5)+(7*9)+(6*0)+(5*3)+(4*7)+(3*2)+(2*2)+(1*3)=159
159 % 10 = 9
So 590372-23-9 is a valid CAS Registry Number.
590372-23-9Relevant academic research and scientific papers
Recommendable routes to trifluoromethyl-substituted pyridine- and quinolinecarboxylic acids
Cottet, Fabrice,Marull, Marc,Lefebvre, Olivier,Schlosser, Manfred
, p. 1559 - 1568 (2007/10/03)
As part of a case study, rational strategies for the preparation of all ten 2-, 3-, or 4-pyridinecarboxylic acids and all nine 2-, 3-, 4-, or 8-quinolinecarboxylic acids bearing trifluoromethyl substituents at the 2-, 3-, or 4-position were elaborated. The trifluoromethyl group, if not already present in the precursor, was introduced either by the deoxygenative fluorination of suitable carboxylic acids with sulfur tetrafluoride or by the displacement of ring-bound bromine or iodine by trifluoromethylcopper generated in situ. The carboxy function was produced by treatment of organolithium or organomagnesium intermediates, products of halogen/metal or hydrogen/ metal permutation, with carbon dioxide. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
