590409-82-8Relevant academic research and scientific papers
D-Phe-Pro-Arg type thrombin inhibitors: Unexpected selectivity by modification of the P1 moiety
Lange, Udo E. W.,Baucke, Dorit,Hornberger, Wilfried,Mack, Helmut,Seitz, Werner,Hoeffken, H. Wolfgang
, p. 2029 - 2033 (2003)
Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray struc
