590417-56-4

Usage

Uses

Used in Organic Synthesis:
B-(1-methyl-1H-indol-4-yl)-Boronic acid is used as a reagent in organic synthesis for the construction of complex organic molecules. Its unique structure allows it to participate in various chemical reactions, facilitating the synthesis of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, B-(1-methyl-1H-indol-4-yl)-Boronic acid is used as a key component in the development of new medications and bioactive molecules. Its ability to form reversible covalent bonds makes it an ideal candidate for creating molecules that can interact with specific biological targets, potentially leading to the discovery of novel therapeutic agents.
Used in Medicinal Chemistry for Targeting Biological Receptors and Enzymes:
B-(1-methyl-1H-indol-4-yl)-Boronic acid is utilized in medicinal chemistry as a tool for targeting specific biological receptors and enzymes. Its unique bonding capabilities enable the design of molecules that can selectively bind to and modulate the activity of these targets, which is crucial for the development of effective drugs.
Used in Suzuki and Sonogashira Coupling Reactions:
In the field of chemical reactions, B-(1-methyl-1H-indol-4-yl)-Boronic acid is used as a reagent in Suzuki and Sonogashira coupling reactions. These reactions are essential for the formation of carbon-carbon and carbon-heteroatom bonds, respectively, and are widely used in the synthesis of various organic compounds, including those with potential pharmaceutical applications.

Upstream product

• 77801-91-3 4-chloro-1-methyl-1H-indole 
• 590417-55-3 4-bromo-1-methyl-1H-indole 

Downstream Products

• 1353647-38-7 C₂₂H₂₃N₅O 

Relevant academic research and scientific papers

Scope of the palladium-catalyzed aryl borylation utilizing bis-boronic acid

The Suzuki-Miyaura reaction has become one of the more useful tools for synthetic organic chemists. Until recently, there did not exist a direct way to make the most important component in the coupling reaction, namely the boronic acid. Current methods to make boronic acids often employ harsh or wasteful reagents to prepare boronic acid derivatives and require additional steps to afford the desired boronic acid. The scope of the previously reported palladium-catalyzed, direct boronic acid synthesis is unveiled, which includes a wide array of synthetically useful aryl electrophiles. It makes use of the newly available second generation Buchwald XPhos preformed palladium catalyst and bis-boronic acid. For ease of isolation and to preserve the often sensitive C-B bond, all boronic acids were readily converted to their more stable trifluoroborate counterparts.

Substituted phenylalkanoic acid derivatives and use thereof

A compound represented by the formula (I) or a salt thereof: wherein n represents an integer of 1 to 3, R represents an alkyl group having 3 to 8 carbon atoms, a group represented by the following formula: R1(CH2)k— (wherein k represents 0 or an integer of 1 to 3; R1 represents a saturated cyclic alkyl group having 3 to 7 carbon atoms or a saturated condensed cyclic alkyl group having 6 to 8 carbon atoms, and the group R1 may be substituted with a lower alkyl group having 1 to 4 carbon atoms) and the like, and Ar represents a condensed bicyclic group such as naphthalen-1-yl group, which has suppressing action on prostaglandin and leukotriene production and is useful for prophylactic and/or therapeutic treatment of various inflammatory diseases and the like caused by these lipid mediators.