590417-55-3

Basic information

• Product Name: 4-BROMO-1-METHYL-1H-INDOLE
• Synonyms: 4-BROMO-1-METHYL-1H-INDOLE;4-Bromo-1-methyl-1H-indole 97%;4-Bromo-1-methylindole
• CAS NO: 590417-55-3
• Molecular Formula: C₉H₈BrN
• Molecular Weight: 210.07
• Mol File: 590417-55-3.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 300.878 °C at 760 mmHg
• Flash Point: 110°(230°F)
• Appearance: Colorless to yellow/Liquid
• Density: 1.456 g/mL at 25 °C
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.6360
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 4-BROMO-1-METHYL-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-1-METHYL-1H-INDOLE(590417-55-3)
• EPA Substance Registry System: 4-BROMO-1-METHYL-1H-INDOLE(590417-55-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 590417-55-3(Hazardous Substances Data)

Usage

General Description

4-BROMO-1-METHYL-1H-INDOLE is a chemical compound with the molecular formula C9H8BrN. It is a brominated derivative of 1-methyl-1H-indole and is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. This chemical compound is a pale yellow to light brown crystalline powder with a melting point of around 129-131°C. It is primarily used in the manufacturing of organic compounds for a variety of applications and industries. However, it is important to handle this chemical compound with care as it may pose health risks if not properly managed.

InChI:InChI=1/C9H8BrN/c1-11-6-5-7-8(10)3-2-4-9(7)11/h2-6H,1H3

Upstream product

• 74-88-4 methyl iodide 
• 348640-06-2 4-bromo-7-azaindole 
• 86626-40-6 4-bromo-1-methylindoline 
• 865-33-8 potassium methanolate 
• 90481-72-4 4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indole 
• 52488-36-5 4-bromo-1H-indole 
• 616-38-6 carbonic acid dimethyl ester 
• 431-47-0 trifluoroacetic acid-methyl ester 

Downstream Products

• 120160-29-4 1-(1-methyl-1H-indol-4-yl)-ethanone 

Relevant articles and documents

A Ten-Step Total Synthesis of Speradine C

The first total synthesis of speradine C has been achieved in only ten steps from a commercially available 4-bromoindole. Salient features of the work are the formation of four rings through three cyclizations, namely a bioinspired [3+2] annulation to form the C/D rings, an NCS-mediated oxidation to construct the E ring, and a Ru-catalyzed ketohydroxylation to assemble the F ring. This work highlights how strategic ring constructions can streamline the synthesis of polycyclic compounds.

Rhodium(II)-Catalyzed [4+3] Cyclization of Triazoles with Indole Derivatives and Its Application in the Total Synthesis of (±)-Aurantioclavine

An efficient rhodium(II)-catalyzed [4+3] cyclization reaction of 1-sulfonyl-1,2-3-triazoles and indoles was developed. Azepino[5,4,3- cd]indoles, which are widely distributed in ergot alkaloids with various biological activities, could be obtained in good

Method for preparing indole compound through air oxidation catalyzed by N-hydroxyphthalimide

The invention discloses a method for preparing an indole compound through non-transition metal catalyzed air oxidation. According to the method, the low-cost N-hydroxyphthalimide is used as a catalystand air is used as an oxidizing agent, wherein indoline compounds are oxidized in an organic solvent, and synthesis of the indoline compounds is achieved. The method has the advantages of simple reaction operation, low reaction cost, high yield, mild conditions, no heavy metal pollution and the like.