590417-97-3

Usage

Uses

Used in Organic Synthesis:
2H-Indazole,5-bromo-2-ethyl-(9CI) is used as a building block for the synthesis of various bioactive compounds and drug molecules. Its unique structure and functional groups make it a valuable and versatile tool in chemical research.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2H-Indazole,5-bromo-2-ethyl-(9CI) is used for the development of new pharmaceutical agents. Its chemical properties and structural features can be exploited to design and synthesize novel drug candidates with potential therapeutic applications.
Used in Pharmaceutical Research:
2H-Indazole,5-bromo-2-ethyl-(9CI) is utilized in pharmaceutical research to explore its potential as a precursor for the synthesis of new drugs. Researchers can investigate its chemical reactivity, stability, and other properties to optimize its use in drug discovery and development processes.
It is important for researchers and scientists to consider the potential hazards and risks associated with the handling and use of 2H-Indazole,5-bromo-2-ethyl-(9CI), and to use appropriate safety measures and precautions. This ensures the safe and effective application of the compound in various research and development activities.

Upstream product

• 74-96-4 ethyl bromide 
• 53857-57-1 5-bromo-1H-indazole 
• 75-03-6 ethyl iodide 

Relevant academic research and scientific papers

2,3-DISUBSTITUTED PYRIDINE COMPOUNDS AS TGF-BETA INHIBITORS AND METHODS OF USE

The invention described herein comprises compounds of formula (IV) and a method of treating cancer comprising administering to a subject having cancer one of the compounds in conjunction with another therapeutic treatment of cancer. The compounds (IV) inhibit signaling by a member of the TGF-β superfamily such as Nodal or Activin.

The Suzuki reaction applied to the synthesis of novel pyrrolyl and thiophenyl indazoles

The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K2CO3, dimethoxyethane and Pd(dppf)Cl2 as catalyst, gave the corresponding adducts in good yields. The methodology allows the facile production of indazole-based heteroaryl compounds, a unique architectural motif that is ubiquitous in biologically active molecules.

IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (a) and include tautomers, solvates, prodrugs, esters, and deuterates thereof, and pharmaceutically acceptable salts of said compounds, tautomers, solvates, prodrugs, esters, and deuterates, wherein each of R1, R2, R3, R4, R5, R9, ring A, ring B, ring C, m, n, p, q, -L1-, -L2-,L3-, and L4 - is selected independently and as defined herein. The compounds of the invention have, surprisingly and advantageously, improved solution stability. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Abeta) protein, including Alzheimers Disease, are also disclosed

3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES

The present invention provides 3-indazoyl-4-pyridylisothiazoles or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and methods of using the same, as well as processes for preparing the same, and intermediates thereof.

Substituted phenylalkanoic acid derivatives and use thereof

A compound represented by the formula (I) or a salt thereof: wherein n represents an integer of 1 to 3, R represents an alkyl group having 3 to 8 carbon atoms, a group represented by the following formula: R1(CH2)k— (wherein k represents 0 or an integer of 1 to 3; R1 represents a saturated cyclic alkyl group having 3 to 7 carbon atoms or a saturated condensed cyclic alkyl group having 6 to 8 carbon atoms, and the group R1 may be substituted with a lower alkyl group having 1 to 4 carbon atoms) and the like, and Ar represents a condensed bicyclic group such as naphthalen-1-yl group, which has suppressing action on prostaglandin and leukotriene production and is useful for prophylactic and/or therapeutic treatment of various inflammatory diseases and the like caused by these lipid mediators.