59058-36-5Relevant academic research and scientific papers
Design and synthesis of potent and subtype-selective PPARα agonists
Desai, Ranjit C.,Metzger, Edward,Santini, Conrad,Meinke, Peter T.,Heck, James V.,Berger, Joel P.,MacNaul, Karen L.,Cai, Tian-Quan,Wright, Samuel D.,Agrawal, Arun,Moller, David E.,Sahoo, Soumya P.
, p. 1673 - 1678 (2007/10/03)
Beginning with a moderately potent PPARγ agonist 9, a series of potent and highly subtype-selective PPARα agonists was identified through a systematic SAR study. Based on the results of the efficacy studies in the hamster and dog models of dyslipidemia and the desired pharmacokinetic data, the optimized compound 39 was selected for further profiling.
Benzyloxy derivatives as MAOB inhibitors
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Page/Page column 10, (2008/06/13)
The invention relates to compounds of the formula and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, n, m, and o are as defined in the specification. The compounds are selective monoamine oxidase β inhibitors and are useful for the treatment and prevention of Alzheimer's disease and senile dementia, as well as other CNS disorders. The invention also relates to processes for preparing such compounds and pharmaceutical compositions containing them.
Novel herbicidally active, nuclear-substituted phenoxy-phenoxy-alkanecarboxylic acid derivatives and use thereof for controlling grass-like weeds
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, (2008/06/13)
The invention is concerned with new herbicidally active 4-phenoxy-α-phenoxy-alkanecarboxylic acid derivatives, especially propionic acid esters of the type STR1 bearing in the first phenoxy radical a nitro group besides another substituent R1 w
