59059-43-7

Upstream product

• 109-67-1 1-penten 
• 1750-36-3 (E)-N-benzylidenebenzenamine 
• 6630-33-7 ortho-bromobenzaldehyde 
• 571184-11-7 2-pent-1-ynyl-benzaldehyde 
• 64380-54-7 2-(2-methylphenyl)-1,3-dioxolane 
• 542-69-8 1-iodo-butane 
• 89-95-2 2-methyl-benzyl alcohol 
• 75-03-6 ethyl iodide 
• 529-20-4 2-methylphenyl aldehyde 
• 627-19-0 1-Pentyne 
• 110683-65-3 ((E)-2-Pent-1-enyl)-benzoic acid methyl ester 
• 26311-41-1 methyl o-amylbenzoate 
• 4122-56-9 methyl o-formylbenzoate 
• 110683-66-4 o-amylbenzyl alcohol 

Downstream Products

• 110683-35-7 o-amylcinnamic acid 
• 26311-42-2 2-n-pentylbenzoic acid 
• 1426121-77-8 C₃₂H₅₀N₂ 
• 3413-15-8 butylphthalide 
• 110698-31-2 (E)-3-(2-Pentyl-phenyl)-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-acrylamide 
• 103178-04-7 2-Pentyl-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-benzamide 
• 103175-75-3 4-Pentyl-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-benzamide 

Relevant academic research and scientific papers

Photocontrol of Polar Aromatic Interactions by a Bis-Hemithioindigo Based Helical Receptor

The first example of a bis-hemithioindigo (bis-HTI)-based molecular receptor was realized. Its folding and selective binding affinity for aromatic guest molecules can be precisely controlled by visible light and heat. The thermodynamically stable state of the bis-HTI is the s-shaped planar Z,Z-configuration. After irradiation with 420 nm light only the E,Z-configuration is formed in a highly selective photoisomerization. The E,Z-isomer adopts a helical conformation because of the implementation of repulsive steric interactions. The E,Z-configured helix is able to recognize electron-poor aromatic guests exclusively through polar aromatic interactions and also distinguishes between regioisomers. After heating, the Z,Z-configuration is completely restored and the aromatic guest molecule is efficiently released.

Rhodium-catalyzed ortho-alkylation of aromatic aldimines and ketimines via C-H bond activation

The aldimines reacted with alkenes under a rhodium catalytic system, Rh[(coe)2Cl]2 and Cy3P, to give mainly the double alkylated products with moderate to high yields. On the other hand, the ketimine 9 gave the mono alkylated product predominantly.

COMPOUNDS REDUCING MALODOUR PERCEPTION AND THE USE THEREOF

The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3,R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.

NOVEL SINGLE STEP ESTERIFICATION PROCESS OF ALDEHYDES USING A HETEROGENEOUS CATALYST

The present invention relates to a novel simple, efficient and single-step process for esterification of aldehydes using a heterogeneous catalyst with high yields. More particularly, the present invention relates to a novel simple, efficient and single-step process for esterification of aldehydes using Titanium superoxide with greater than 80% yields.

Titanium superoxide-a stable recyclable heterogeneous catalyst for oxidative esterification of aldehydes with alkylarenes or alcohols using TBHP as an oxidant

Titanium superoxide efficiently catalysed the oxidative esterification of aldehydes with alkylarenes or alcohols, under truly heterogeneous conditions, to afford the corresponding benzyl and alkyl esters in excellent yields. Mechanistic studies have established that this "one pot" direct oxidative esterification process proceeds through a radical pathway, proven by a FTIR spectral study of a titanium superoxide-aldehyde complex as well as spin trapping experiments with TEMPO. The intramolecular version of this protocol has been successfully demonstrated in the concise synthesis of 3-butylphthalide, an anti-convulsant drug.

Antimycobacterial activity evaluation, time-kill kinetic and 3D-QSAR study of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives

A series of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives were synthesized and evaluated for their antitubercular activity. Some of the compounds exhibited potent activity against Mycobacterium tuberculosis H37Rv. One of the compound having t-butyl at para position of the benzene ring showed excellent activity even better than the standard drug ethambutol with MIC value 1.1 ± 0.2 μM. The time-kill kinetics study of two most active compounds showed rapid killing of the M. tuberculosis within 4 days. Additionally atom-based quantitative structure-activity relationship (QSAR) model was developed that gave a statistically satisfying result (R2) = 0.92, Q2 = 0.75, Pearson-R = 0.96 and effectively predicts the anti-tuberculosis activity of training and test set compounds.

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships

(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.