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Usage

Uses

Used in Pharmaceutical Industry:
ISOTHIAZOLINE 1,1-DIOXIDE is used as an antimicrobial agent for the prevention of microbial contamination in pharmaceutical products. Its application reason is to maintain the sterility and safety of medications, ensuring their efficacy and reducing the risk of infection.
Used in Personal Care Industry:
In the personal care industry, ISOTHIAZOLINE 1,1-DIOXIDE is used as a preservative in cosmetics, skincare, and hair care products. The application reason is to prevent the growth of bacteria, fungi, and other microorganisms that can cause spoilage and potential health risks.
Used in Industrial Water Treatment:
ISOTHIAZOLINE 1,1-DIOXIDE is also used in the industrial water treatment sector as a biocide to control the growth of microorganisms in cooling systems and other water-based systems. The application reason is to prevent the formation of biofilms, fouling, and corrosion, which can lead to system inefficiencies and increased maintenance costs.
Used in Agriculture:
In agriculture, ISOTHIAZOLINE 1,1-DIOXIDE is used as a fungicide and bactericide to protect crops from diseases caused by various pathogens. The application reason is to improve crop yield and quality by reducing the impact of diseases on plants.
Used in Textile Industry:
In the textile industry, ISOTHIAZOLINE 1,1-DIOXIDE is used as an antimicrobial agent in the treatment of fabrics and fibers. The application reason is to provide odor control, prevent the growth of mold and mildew, and enhance the durability of textile products.
Used in Paints and Coatings Industry:
ISOTHIAZOLINE 1,1-DIOXIDE is used in the paints and coatings industry as a biocide to prevent the growth of microorganisms that can cause discoloration, spoilage, and degradation of the paint or coating. The application reason is to maintain the aesthetic and protective properties of the coatings, ensuring their longevity and performance.
Used in Propane Sultam Synthesis:
ISOTHIAZOLINE 1,1-DIOXIDE is used as a reactant in the synthesis of orally bioavailable hepatitis B caspid inhibitors and in the preparation of cryptochrome inhibitors as antidiabetic agents. The application reason is to contribute to the development of new pharmaceutical compounds with potential therapeutic benefits for various health conditions.

Upstream product

• 108214-47-7 N-nitrosopropanesultam 

Downstream Products

• 500732-66-1 2-(3-benzyl-5-bromo-benzyl)-isothiazolidine 1,1-dioxide 
• 89151-10-0 2-[2-(pyridin-4-yl)ethyl]isothiazolidine-1,1-dioxide 
• 1036647-92-3 3-benzyloxy-7-(1,1-dioxo-isothiazolidin-2-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid 4-fluoro-benzylamide 
• 1122482-42-1 C₂₀H₂₂N₂O₅S 
• 73825-54-4 2-(4-methoxy-phenyl)-isothiazolidine 1,1-dioxide 
• 1207356-82-8 C₁₀H₁₃N₃O₄S 
• 158090-60-9 2-(4-pyridyl)-1,2-isothiazolidine-1,1-dioxide 
• 1237802-44-6 C₂₄H₂₄F₅NO₅S₂ 
• 1202923-80-5 3-benzyloxy-9-(1,1-dioxo-isothiazolidin-2-yl)-2-[5-(4-fluoro-benzyl)-thiazol-2-yl]-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one 
• 1114559-48-6 (S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(2-(1,1-dioxo-isothiazolidin-2-yl)ethyl)-6-phenyl-1,3-oxazinan-2-one 
• 74220-58-9 2-(p-tolyl)-1,2-thiazolidine 1,1-dioxide 
• 1353629-00-1 C₁₂H₁₅NO₄S 
• 1570498-89-3 2-(3-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-1-yl)methyl)phenyl)isothiazolidine 1,1-dioxide 
• 76906-24-6 2-phenylisothiazolidine 1,1-dioxide 

Relevant academic research and scientific papers

Development of a novel sulfonate ester-based prodrug strategy

A self-immolative γ-aminopropylsulfonate linker was investigated for use in the development of prodrugs that are reactive to various chemical or biological stimuli. To demonstrate their utility, a leucine-conjugated prodrug of 5-chloroquinolin-8-ol (5-Cl-8-HQ), which is a potent inhibitor against aminopeptidase from Aeromonas proteolytica (AAP), was synthesized. The sulfonate prodrug was considerably stable under physiological conditions, with only enzyme-mediated hydrolysis of leucine triggering the subsequent intramolecular cyclization to simultaneously release 5-Cl-8-HQ and form γ-sultam. It was also confirmed that this γ-aminopropylsulfonate linker was applicable for prodrugs of not only 8-HQ derivatives but also other drugs bearing a phenolic hydroxy group.

N-Nitroso Sultams: On the Direction of Approach of Nucleophiles to the Sulfonyl Group

The N-nitroso derivatives of propanesultam, butanesultam, and pentanesultam were synthesized along with N-nitropropanesultam and N-nitro-N-methylmethanesulfonamide.The decompositions of the N-nitroso sultams, wich increase in rate with increasing ring size, yield the corresponding sultones and also varying amounts of regenerated sultams.These reactions are discussed in terms of higher energy pathway involving approach of the nucleophile in a direction between of sulfonyl oxygens (on the O, O, N face) and a lower energy pathway involving the conformer which permits approach of the nucleophile trans to and colinear with one of the coordinate covalent oxygen atoms (on R, O, N face). The mechanisms of the decomposition of the N-nitro sulfonamides and the tosyloxy diimide N-oxides are also discussed.N-nitrosopropanesultam (and the butyl analoque) are potent inhibitors of proteinase α-chymotrypsin.