76906-24-6

Upstream product

• 36320-71-5 3-bromopropyl thiocyanate 
• 90415-85-3 3-chloro-N-phenylpropane-1-sulfonamide 
• 5908-62-3 isothiazolidine 1,1-dioxide 
• 591-50-4 iodobenzene 
• 62-53-3 aniline 

Downstream Products

• 905975-30-6 (1,1-dioxo-2-phenyl-1λ⁶-isothiazolidin-5-yl)-phosphonic acid diethyl ester 
• 905975-34-0 [1-benzyl-2-(1,1-dioxo-2-phenyl-1λ⁶-isothiazolidin-5-ylidene)-ethyl]-carbamic acid tert-butyl ester 
• 905975-38-4 [1-benzyl-2-(1,1-dioxo-2-phenyl-1λ⁶-isothiazolidin-5-ylidene)-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Low catalyst loadings for ligand-free copper(I)-oxide-catalyzed N-arylation of methanesulfonamide in water

A simple and practical protocol for the cross-coupling of methanesulfonamide and aryl iodides under ligand-free copper(I)-oxide-catalyzed conditions in water is reported. The method allows the preparation of a wide variety of synthetically useful N-arylated methanesulfonamides in good to excellent yields (up to 90 %) under the optimized conditions. A convenient and efficient ligand-free method using a copper(I) oxide catalyst at 130 °C in water was developed for the N-arylation of methanesulfonamide with aryl iodides. A variety of functionalized aliphatic and cyclic sulfonamides were coupled with different substituted aryl halides to give the corresponding N-arylated products in good to excellent yields under the optimized conditions. Copyright

Low Catalyst Loadings for Ligand-Free Copper(I)-Oxide-Catalyzed N-Arylation of Methanesulfonamide in Water

A simple and practical protocol for the cross-coupling of methanesulfonamide and aryl iodides under ligand-free copper(I)-oxide-catalyzed conditions in water is reported. The method allows the preparation of a wide variety of synthetically useful N-arylated methanesulfonamides in good to excellent yields (up to 90 %) under the optimized conditions.

Dipeptide vinyl sultams: Synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum

The synthesis of phosphonate derivatives of N-phenyl- and N-benzyl-γ- and δ-sultams, and their application in the Wittig-Horner reaction with N-Boc-l-phenylalanine aldehyde to afford E- and Z-isomers, are described. These compounds were further processed to provide five dipeptide vinyl sultams, which were found to be inactive against papain at concentrations up to 50 μM. In contrast, vinyl sultams demonstrated weak activity against recombinant falcipain-2 and Plasmodium falciparum W2.