59083-39-5

Basic information

• Product Name: 4-(4-METHYLPHENYL)PIPERIDINE
• Synonyms: 4-P-TOLYL-PIPERIDINE;4-(4-METHYLPHENYL)PIPERIDINE;Piperidine, 4-(4-methylphenyl)-
• CAS NO: 59083-39-5
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.27
• Mol File: 59083-39-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 282℃
• Flash Point: 127℃
• Appearance: /
• Density: 0.958
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 4-(4-METHYLPHENYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHYLPHENYL)PIPERIDINE(59083-39-5)
• EPA Substance Registry System: 4-(4-METHYLPHENYL)PIPERIDINE(59083-39-5)

Safety Data

• Statements: 52
• Hazardous Substances Data: 59083-39-5(Hazardous Substances Data)

Usage

General Description

4-(4-Methylphenyl)piperidine, also known as 4-MPHP, is a psychoactive stimulant drug that belongs to the cathinone class. It is a synthetic compound that acts as a releasing agent of serotonin, norepinephrine, and dopamine in the brain. 4-MPHP has been reported to produce euphoric and stimulating effects, as well as increased sociability and empathy. Its potential for abuse and addiction has led to its classification as a controlled substance in some countries. Additionally, its long-term effects on the brain and body are not well understood, and its use has been associated with negative health outcomes. Due to these risks, 4-MPHP is not approved for medical use and is considered a research chemical.

InChI:InChI=1/C12H17NO/c1-14-12-4-2-10(3-5-12)11-6-8-13-9-7-11/h2-5,11,13H,6-9H2,1H3

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 104-87-0 4-methyl-benzaldehyde 
• 59612-76-9 3-(4-methylphenyl)pentan-1,5-dioic acid 
• 2017-88-1 ethyl (E)-2-cyano-3-p-tolylacrylate 
• 10602-01-4 p-bromobenzaldehyde 1,3-dioxolane 
• 2403-51-2 2-(4-methylphenyl)-1,3-dioxolane 
• 694-05-3 1,2,3,6-tetrahydropyridine 
• 108-88-3 toluene 

Downstream Products

• 180157-54-4 (2S)-(-)-1-(4-indolyloxy)-3-(4-(4-methylphenyl)piperidin-1-yl)-2-propanol ethanedioate 
• 1027354-92-2 (3-amino-4-methyl-phenyl)-[4-(4-methylphenyl)-1-piperidyl]methanone 
• 1255390-55-6 2-(4-para-tolylpiperidin-1-yl)benzo[d]oxazole 
• 1246082-89-2 6-(2-(4-p-tolylpiperidin-1-yl)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 

Relevant articles and documents

20-HETE FORMATION INHIBITORS

This disclosure provides novel heterocyclic compounds and methods for inhibiting the enzyme CYP4. Further disclosed methods include: a method of inhibiting the biosynthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) in a subject in need thereof and a method of producing neuroprotection and decreased brain damage by preventing cerebral microvascular blood flow impairment and anti-oxidant mechanisms in a subject experiencing or having experienced an ischemic event.

BENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Superacid-catalyzed preparation of aryl-substituted piperidines via dicationic electrophiles

The electrophilic chemistry of 1,2,3,6-tetrahydropyridines has been studied in the Bronsted superacid, CF3SO3H (triflic acid). The 1,2,3,6-tetrahydropyridines react with arenes to give aryl-substituted piperidines. It is proposed tha