59084-08-1

Basic information

• Product Name: ETHYL-1-BENZYL-4-PIPERINE CARBOXYLATE
• Synonyms: ETHYL-1-BENZYL-4-PIPERINE CARBOXYLATE;1-Benzyl-4-phenyl-piperidine-4-carboxylic acid ethyl este;1-Benzyl-4-phenyl-4-piperidinecarboxylic Acid Ethyl Ester
• CAS NO: 59084-08-1
• Molecular Formula: C₂₁H₂₅NO₂
• Molecular Weight: 323.434
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 59084-08-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL-1-BENZYL-4-PIPERINE CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL-1-BENZYL-4-PIPERINE CARBOXYLATE(59084-08-1)
• EPA Substance Registry System: ETHYL-1-BENZYL-4-PIPERINE CARBOXYLATE(59084-08-1)

Safety Data

• Hazardous Substances Data: 59084-08-1(Hazardous Substances Data)

Usage

Uses

1-Benzyl-4-phenyl-4-piperidinecarboxylic Acid Ethyl Ester is an impurity of the analgesic Meperidine (M223900).

Upstream product

• 55-51-6 N,N-bis(2-chloro-ethyl)-benzenemethanamine 
• 101-32-6 N-benzyl-diethanolamine 
• 723272-14-8 4-bromo-2-(2-bromo-ethyl)-2-phenyl-butyric acid 
• 40481-13-8 4-phenyl-4-cyanopiperidine 
• 64-17-5 ethanol 
• 56243-25-5 1-benzyl-4-cyano-4-phenylpiperidine 
• 854432-10-3 4-bromo-2-(2-bromo-ethyl)-2-phenyl-butyric acid ethyl ester 
• 100-46-9 benzylamine 
• 61886-17-7 1-benzyl-4-phenyl-piperidine-4-carboxylic acid 

Downstream Products

• 546-32-7 4-Phenyl-1-(2-hydroxy-2-phenyl-ethyl)-4-ethoxycarbonyl-piperidin 
• 77-17-8 Normeperidine 

Relevant articles and documents

Opioids and efflux transporters. Part 1: P-Glycoprotein substrate activity of N-substituted analogs of meperidine

P-Glycoprotein (P-gp) is an efflux transporter which is up-regulated at the blood-brain barrier in both morphine- and oxycodone-tolerant rats. Numerous studies have shown that many clinically employed opioid analgesics are substrates for P-gp, suggesting that up-regulation of P-gp may contribute to the development of central tolerance to opioids. The studies herein focus on the development of SAR for P-gp substrate activity in the meperidine series of compounds, and show that a meperidine analog of greater potency, N-phenylbutyl-N-normeperidine, has low activity as a P-gp substrate and has the potential to be utilized as a tool to study the contribution of P-gp to the development of central tolerance to opioids.