61886-17-7

Basic information

• Product Name: 1-benzyl-4-phenylpiperidine-4-carboxylic acid
• Synonyms: 1-benzyl-4-phenylpiperidine-4-carboxylic acid;4-Phenyl-1-phenylmethyl-4-piperidinecarboxylic acid;1-benzyl-4-phenylpiperidine-4-carboxylic acid(SALTDATA: 0.6H2O)
• CAS NO: 61886-17-7
• Molecular Formula: C₁₉H₂₁NO₂
• Molecular Weight: 295.37554
• EINECS: 263-282-6
• Mol File: 61886-17-7.mol

Chemical Properties

• Boiling Point: 454.7°C at 760 mmHg
• Flash Point: 228.8°C
• Appearance: /
• Density: 1.178g/cm³
• Vapor Pressure: 4.66E-09mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 1-benzyl-4-phenylpiperidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-phenylpiperidine-4-carboxylic acid(61886-17-7)
• EPA Substance Registry System: 1-benzyl-4-phenylpiperidine-4-carboxylic acid(61886-17-7)

Safety Data

• Hazardous Substances Data: 61886-17-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
1-benzyl-4-phenylpiperidine-4-carboxylic acid is utilized as a key intermediate in the synthesis of various pharmaceuticals due to its potential pharmacological properties. Its structure allows for the development of compounds that may target neurological disorders and pain management, offering new therapeutic options for patients.
Used in Medicinal Chemistry Research:
As a member of the piperidine derivatives family, 1-benzyl-4-phenylpiperidine-4-carboxylic acid serves as a valuable compound in medicinal chemistry research. Scientists explore its interactions with biological targets and evaluate its efficacy and safety in treating specific conditions, contributing to the advancement of drug discovery and development.

InChI:InChI=1/C19H21NO2/c21-18(22)19(17-9-5-2-6-10-17)11-13-20(14-12-19)15-16-7-3-1-4-8-16/h1-10H,11-15H2,(H,21,22)

Upstream product

• 56243-25-5 1-benzyl-4-cyano-4-phenylpiperidine 
• 101-32-6 N-benzyl-diethanolamine 
• 103-82-2 phenylacetic acid 
• 55-51-6 N,N-bis(2-chloro-ethyl)-benzenemethanamine 

Downstream Products

• 84176-76-1 1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide 
• 59084-08-1 1-benzyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester 
• 3627-45-0 4-phenyl-piperidine-4-carboxylic acid 
• 77-17-8 Normeperidine 
• 1013329-92-4 (1-benzyl-4-phenylpiperidin-4-yl)(4-methylpiperazin-1-yl)methanone 

Relevant articles and documents

Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elevated blood glucose in a murine model of type II diabetes.

Compounds with analgesic and local anaesthetic effect

New compounds of the formula (A) STR1 a process for their preparation and their use in the manufacture of pharmaceutical preparations. The new compounds have both local anaesthetic and analgesic effect.

Compounds with analgesic and local anaesthetic effect

New compounds of the formula (A) STR1 a process for their preparation and their use in the manufacture of pharmaceutical preparations. The new compounds have both local anaesthetic and analgesic effect.

1-AZONIABICYCLO[2.2.1]HEPTANES, METHODS OF PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT

The invention relates to quaternary basic amides of the formula STR1 in which Ar is an optionally substituted mono-, di-or tricyclic aromatic or heteroaromatic group;T is a direct bond, a hydroxymethylene group, an alkoxymethylene group in which the alkoxy group is C 1-C. sub.4, or a C 1-C 5-alkylene group; Ar' is an unsubstituted or mono-or poly-substituted phenyl, a thienyl, a benzothienyl, a naphthyl or an indolyl; R is hydrogen or a C 1-C. sub.4-alkyl, or a C 1-C 4-ω-alkoxy(C 2-C 4) alkyl, or a C 2-C 4-ω-alkanoyloxy (C 1-C 4)alkyl;.Q is hydrogen;or else Q and R together form a 1,2-ethylene, 1,3-propylene or 1,4-butylene group;Am ⊕ is the radical STR2 in which X 1, X 2 and X 3, together with the nitrogen atom to which they are bonded, form a 1-AZONIABICYCLO[2.2.1] HEPTANE optionally substituted by a phenyl or benzyl group; and A . crclbar. is a pharmaceutically acceptable anion. These compounds are useful for the preparation of drugs intended for the treatment of pathological conditions involving the tachykinin system.