591-86-6 Usage
Uses
Used in Pharmaceutical Production:
Acetaldehyde semicarbazone is used as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications.
Used in Dye Production:
ACETALDEHYDE SEMICARBAZONE serves as a key component in the production of dyes, enhancing the color and quality of various products.
Used in Resin and Plastic Production:
Acetaldehyde semicarbazone is utilized in the manufacturing process of resins and plastics, improving their properties and performance in various applications.
Used in Antimicrobial Applications:
Due to its antimicrobial properties, acetaldehyde semicarbazone is studied for its potential use in treating bacterial infections and diseases.
Used in Antiviral Applications:
The antiviral characteristics of acetaldehyde semicarbazone make it a candidate for research in the treatment of viral infections and related diseases.
Used in Chemical Synthesis and Analysis:
As a reagent, acetaldehyde semicarbazone is employed in various chemical synthesis processes and analytical techniques, aiding in the development and understanding of chemical compounds and reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 591-86-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,9 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 591-86:
(5*5)+(4*9)+(3*1)+(2*8)+(1*6)=86
86 % 10 = 6
So 591-86-6 is a valid CAS Registry Number.
591-86-6Relevant academic research and scientific papers
Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors
Zhang, Han,Liu, Huan,Luo, Xiao,Wang, Yuxi,Liu, Yuan,Jin, Hongwei,Liu, Zhenming,Yang, Wei,Yu, Peilin,Zhang, Liangren,Zhang, Lihe
, p. 235 - 252 (2018/05/09)
Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable cationic channel, plays critical roles in insulin release, cytokine production, body temperature regulation and cell death as a reactive oxygen species (ROS) and temperature sensor. However, few TRPM2 inhibitors have been reported, especially TRP-subtype selective inhibitors, which hampers the investigation and validation of TRPM2 as a drug target. To discover novel TRPM2 inhibitors, 3D similarity-based virtual screening method was employed, by which 2,3-dihydroquinazolin-4(1H)-one derivative H1 was identified as a TRPM2 inhibitor. A series of novel 2,3-dihydroquinazolin-4(1H)-one derivatives were subsequently synthesized and characterized. Their inhibitory activities against the TRPM2 channel were evaluated by calcium imaging and electrophysiology approaches. Some of the compounds exhibited significant inhibitory activity, especially D9 which showed an IC50 of 3.7 μM against TRPM2 and did not affect the TRPM8 channel. The summarized structure-activity relationship (SAR) provides valuable insights for further development of specific TRPM2 targeted inhibitors.
