59108-54-2

Usage

Uses

Used in Pharmaceutical Industry:
(S)-chroMan-3-aMine hydrochloride is used as a therapeutic agent for the treatment of neurological conditions such as depression, anxiety, and schizophrenia. Its agonistic action on serotonin receptors can help modulate the symptoms associated with these conditions.
Used in Scientific Research:
In the field of scientific research, (S)-chroMan-3-aMine hydrochloride is utilized as a research tool to study the effects of serotonin receptor activation on mood, behavior, and cognition. It aids in understanding the underlying mechanisms of neurological disorders and the role of serotonin in these conditions.
Used in Psychopharmacology:
Due to its psychoactive properties, (S)-chroMan-3-aMine hydrochloride is of interest in psychopharmacology for both research and potential therapeutic applications. Its effects on mood and cognition make it a candidate for further exploration in the development of new treatments for mental health disorders.

Upstream product

• 19090-04-1 chroman-3-one 

Relevant academic research and scientific papers

Asymmetric amination of tetralone and chromanone derivatives employing ω-transaminases

Various (S)-selective and (R)-selective ω-transaminases were investigated for the amination of 1- and 2-tetralone and derivatives as well as of 3- and 4-chromanone. All ketones tested were aminated to give the corresponding enantiopure amines (ee > 99%) employing at least one of the enzymes investigated. In most of the cases the (S)- as well as the (R)-enantiomer was obtained in optically pure form. The amination of 3-chromanone was performed on a 100 mg scale leading to optically pure (R)-3-aminochromane (ee > 99%) with complete conversion and 78% isolated yield.

Alkylation of Tricarbonylchromium-Stabilized Benzylic Anions of 3-(Dipropylamino)chroman

Tricarbonylchromium complexes of racemic and resolved 3-(dipropylamino)chromans were prepared. Benzylic alkylation of the complexes provided access to 4-alkylated derivatives. Alkylations of the endo complex gave only the expected trans products. Unexpectedly, the exo complex predominantly (with methyl iodide) or almost exclusively (with allyl and benzyl bromide) produced the trans derivatives. Steric effects and the nature of the electrophiles appear to direct the outcome of the alkylations.