5911-65-9

Upstream product

• 5096-82-2 benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2-ium hydrobromide 
• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 779276-44-7 C₁₆H₂₁NO₅ 
• 81701-46-4 (E)-4-(2-Benzyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-3-methoxy-but-2-enoic acid methyl ester 
• 81701-54-4 2,9,10-Trimethoxy-1,6,7,11b-tetrahydro-pyrido[2,1-a]isoquinolin-4-one 

Relevant academic research and scientific papers

GLUCOSE METABOLISM MODULATING COMPOUNDS

The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose levels, and/or preventing, treating, or ameliorating the effects of diabetes and hyperglycemia.

HYPOGLYCEMIC DIHYDROPYRIDONES

The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical compositions comprising a compound of formula I, and methods o

Novel hypoglycemic dihydropyridones serendipitously discovered from O- versus C-alkylation in the synthesis of VMAT2 antagonists

Vesicular monoamine transporter type 2 (VMAT2) is a newly emerging target for both diagnostic and therapeutic applications in diabetes mellitus. In pursuit of novel VMAT2 antagonists, we identified a potent hypoglycemic agent with a novel dihydropyridone

Novel Zinc-Promoted Alkylation of Iminium Salts. New Synthesis of Benzylisoquinoline, Phthalidylisoquinoline, and Protoberberine Alkaloids and Related Compounds

Zinc-promoted reductive coupling reaction of iminium salts with alkyl halides was found to be a successful key reaction for synthesis of a variety of alkaloids such as benzylisoquinoline, phthalidylisoquinoline, and protoberberine alkaloids.More specifically, laudanosine, cordrastine, hydrastine, narcotine, tetrahydropalmatine, and canadine were obtained.A new route for the synthesis of the emetine and yohimbine skeletons was exploited.

A NEW SYNTHETIC METHOD OF NITROGEN HETEROCYCLES THROUGH A NOVEL ANNULATION

A new zinc promoted coupling reaction of iminium salts with alkyl halides gave a variety of nitrogen heterocycles through a novel annulation process.