81701-46-4

Upstream product

• 26536-93-6 methyl 4-bromo-3-methoxy-2-butenoate 
• 5096-82-2 benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2-ium hydrobromide 
• 35471-22-8 methyl 4-bromo-3-methoxy-2-butenoate 

Downstream Products

• 841-95-2 9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one 
• 5911-65-9 5,6,9,10,11,11a-Hexahydro-2,3-dimethoxy-8,10-dioxo-8H-benzoquinolizine 

Relevant academic research and scientific papers

Novel Zinc-Promoted Alkylation of Iminium Salts. New Synthesis of Benzylisoquinoline, Phthalidylisoquinoline, and Protoberberine Alkaloids and Related Compounds

Zinc-promoted reductive coupling reaction of iminium salts with alkyl halides was found to be a successful key reaction for synthesis of a variety of alkaloids such as benzylisoquinoline, phthalidylisoquinoline, and protoberberine alkaloids.More specifically, laudanosine, cordrastine, hydrastine, narcotine, tetrahydropalmatine, and canadine were obtained.A new route for the synthesis of the emetine and yohimbine skeletons was exploited.

A NEW SYNTHETIC METHOD OF NITROGEN HETEROCYCLES THROUGH A NOVEL ANNULATION

A new zinc promoted coupling reaction of iminium salts with alkyl halides gave a variety of nitrogen heterocycles through a novel annulation process.