59115-52-5Relevant academic research and scientific papers
Nickel- or Iron-Catalyzed Cross-Coupling of Aryl Carbamates with Arylsilanes
Shi, Wen-Juan,Zhao, Hong-Wei,Wang, Yang,Cao, Zhi-Chao,Zhang, Li-Sheng,Yu, Da-Gang,Shi, Zhang-Jie
, p. 2410 - 2416 (2016)
Aryl carbamates were for the first time applied as electrophiles in the cross-coupling with arylsilanes via nickel or iron catalysis to construct valuable biaryl compounds. This new coupling reaction features a good group tolerance and non-sensitivity to steric hindrance on both aryl carbamates and arylsilanes. (Figure presented.).
Nickel Carbodicarbene Catalyzes Kumada Cross-Coupling of Aryl Ethers with Grignard Reagents through C–O Bond Activation
Ambre, Ram,Yang, Hsuan,Chen, Wen-Ching,Yap, Glenn P. A.,Jurca, Titel,Ong, Tiow-Gan
supporting information, p. 3511 - 3517 (2019/08/12)
The development of a cross-coupling reaction protocol between aryl ethers and Grignard reagents catalyzed by carbodicarbene (CDC) nickel complexes to afford biaryl compounds through C–O cleavage is reported. Aromatic substrates featuring a broad range of electron neutral, donating, or withdrawing groups are introduced at the desired position. The method has proven effective over a wide range of naphthyl methyl ethers, anisoles, and Grignard reagents. The robustness of the protocol is validated by performing multiple cleavage reactions, gram scale synthesis, and arylation of a dimethoxy esterdiol derivative.
