591208-34-3

Upstream product

• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 120465-56-7 4-(dimethoxymethyl)benzoic acid 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 54793-80-5 (S)-proline-(S)-phenylalanine methyl ester 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 23631-72-3 N-carbobenzoxy-L-prolyl-L-phenylalanine methyl ester 

Downstream Products

• 246854-73-9 (S,S)-N-(4-dimethoxymethyl-benzoyl)proline-phenylalanine carboxylic acid hydrazide 

Relevant academic research and scientific papers

Metal-ion induced amplification of three receptors from dynamic combinatorial libraries of peptide-hydrazones

Three building blocks of general structure (MeO)2CH-aromatic linker-Pro-amino acid-NHNH2 have been prepared and tested in acid-catalysed dynamic combinatorial libraries. Exposure of these libraries to LiI and NaI led to the amplification of three macrocyclic pseudopeptide receptors. The receptors were isolated and their interactions with LiI and NaI were analysed using NMR, IR and ITC. Binding of the metal ions to the receptors is invariably entropy-driven. Nevertheless, all receptors were found to be flexible with substantial conformational rearrangements accompanying guest binding. This type of receptor is extremely difficult to access through rational design and the fact that dynamic combinatorial chemistry allows facile access to these challenging molecules underlines the power of the dynamic approach.

Molecular amplification in a dynamic combinatorial library using non-covalent interactions

A trace component within a dynamic combinatorial library of pseudo-peptide hydrazones has been dramatically amplified in a reversible manner through recognition by [18]crown-6.