591217-75-3Relevant academic research and scientific papers
NOVEL HISTONE DEACETYLASE INHIBITOR OF BENZAMIDES AND USE THEREOF
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Paragraph 0014; 0015; 0032; 0055, (2014/05/20)
Disclosed in the present invention is a novel histone deacetylase inhibitor of benzamides and use thereof. The inhibitor has good efficacy in treating diseases caused by abnormal gene expression, such as tumours, endocrine disorders, immune system diseases, genetic diseases and nerve system diseases. The histone deacetylase inhibitor of benzamides is a compound of the following general chemical structural formula (I) or a salt thereof.
NOVEL HISTONE DEACETYLASE INHIBITOR OF BENZAMIDES AND USE THEREOF
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Paragraph 0073-0074; 0143-0146, (2014/08/19)
Disclosed in the present invention is a novel histone deacetylase inhibitor of benzamides and use thereof. The inhibitor has good efficacy in treating diseases caused by abnormal gene expression, such as tumours, endocrine disorders, immune system disease
Potent histone deacetylase inhibitors: N-hydroxybenzamides with antitumor activities
Maeda, Taishi,Nagaoka, Yasuo,Kuwajima, Hiroshi,Seno, Chieko,Maruyama, Sakiko,Kurotaki, Mineko,Uesato, Shinichi
, p. 4351 - 4360 (2007/10/03)
The screening tests of N-hydroxybenzamides for their HDAC-inhibitory activities led to the discovery of the promising compounds with a 2-naphthylcarbonyl group and with a 1,4-biphenylcarbonyl group. These compounds were further modified to optimize their
Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group
Uesato, Shinichi,Kitagawa, Manabu,Nagaoka, Yasuo,Maeda, Taishi,Kuwajima, Hiroshi,Yamori, Takao
, p. 1347 - 1349 (2007/10/03)
Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with t
