591217-76-4Relevant academic research and scientific papers
Potent histone deacetylase inhibitors: N-hydroxybenzamides with antitumor activities
Maeda, Taishi,Nagaoka, Yasuo,Kuwajima, Hiroshi,Seno, Chieko,Maruyama, Sakiko,Kurotaki, Mineko,Uesato, Shinichi
, p. 4351 - 4360 (2007/10/03)
The screening tests of N-hydroxybenzamides for their HDAC-inhibitory activities led to the discovery of the promising compounds with a 2-naphthylcarbonyl group and with a 1,4-biphenylcarbonyl group. These compounds were further modified to optimize their
Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group
Uesato, Shinichi,Kitagawa, Manabu,Nagaoka, Yasuo,Maeda, Taishi,Kuwajima, Hiroshi,Yamori, Takao
, p. 1347 - 1349 (2007/10/03)
Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with t
