591250-19-0

Basic information

• Product Name: methyl 2-[acetyloxymethyl(4,5-dimethoxy-2-nitrophenyl)]acrylate
• Synonyms: methyl 2-[acetyloxymethyl(4,5-dimethoxy-2-nitrophenyl)]acrylate
• CAS NO: 591250-19-0
• Molecular Weight: 339.302
• Mol File: 591250-19-0.mol

Chemical Properties

• CAS DataBase Reference: methyl 2-[acetyloxymethyl(4,5-dimethoxy-2-nitrophenyl)]acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-[acetyloxymethyl(4,5-dimethoxy-2-nitrophenyl)]acrylate(591250-19-0)
• EPA Substance Registry System: methyl 2-[acetyloxymethyl(4,5-dimethoxy-2-nitrophenyl)]acrylate(591250-19-0)

Safety Data

• Hazardous Substances Data: 591250-19-0(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 591250-25-8 methyl 3-(4,5-dimethoxy-2-nitrophenyl)-3-hydroxy-2-methylenepropanoate 
• 20357-25-9 6-nitroveratraldehyde 
• 75-36-5 acetyl chloride 

Downstream Products

• 1150662-55-7 C₁₃H₁₅NO₆ 
• 1197934-94-3 methyl 2-{(4,5-dimethoxy-2-nitrophenyl)[(2-methoxy-2-oxoethyl)amino]methyl}acrylate 

Relevant articles and documents

Synthesis of 2-amino-3,4-dihydroquinazolines and imidazo[2,1-b]quinazoline- 2-ones

A straightforward method for the synthesis of 2-amino-3,4- dihydroquinazolines from Baylis-Hillman derivatives is disclosed. The protocol involves sequential SN2 reaction of a primary amine on the Baylis-Hillman acetate derived from 2-nitrobenzaldehyde, c

Straightforward strategy for the stereoselective synthesis of spiro-fused (C-5)isoxazolino- or (C-3)pyrazolino-(C-3)quinolin-2-ones from Baylis-Hillman adducts by 1,3-dipolar cycloaddition and reductive cyclization

A straightforward and general approach for the stereoselective synthesis of spiro-fused (C-5)isoxazolino- or (C-3)pyrazolino-(C-3)quinolin-2-ones from the adducts offorded from the Baylis-Hillman reaction of 2-nitrobenzaldehyde and ethyl acrylate by sequential 1,3-dipolar cycloaddition and reductive cyclization is presented. It was found that the reductive cyclization of the isoxazoline derivatives proceeded efficiently in the presence of In/HCl, whereas similar reductions of pyrazolines gave better yields when carried out in the presence of an Fe/AcOH mixture. However, similar attempts employing the Baylis-Hillman adduct of 2-nitrobenzaldehyde and methyl vinyl ketone did not yield the desired compounds. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Synthesis of substituted 1H- and 3H-1-benzazepines and rearrangement of alkyl 1H-1-benzazepine-2-carboxylates into isoquinolines

The SnCl2-mediated reduction of nitro groups in 2-nitro-4-(2-nitrobenzylidene)alkanoates and 4-nitro-2-(2-nitroalkylidene) alkanoates allows the facile synthesis of substituted 1H-1-benzazepines and 3H-1-benzazepines. This reaction proceeds via

Synthesis of 3-substituted quinolines via transition-metal-catalyzed reductive cyclization of o-nitro baylis-hillman acetates

Reductive cyclization of o-nitro-substituted Baylis-Hillman acetates by carbon monoxide, catalyzed by [Cp*Fe(CO)2]2, gives moderate to good yields of 3-substituted quinolines.